{"created":"2023-07-27T06:30:06.311448+00:00","id":14983,"links":{},"metadata":{"_buckets":{"deposit":"511aec53-f817-4872-a97c-633ab8574826"},"_deposit":{"created_by":3,"id":"14983","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14983"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00014983","sets":["4281:4291:4312"]},"author_link":["26938","26935","26939","22059","86","2702","26937","26941","26936","26940","26934"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-05-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"217","bibliographicPageStart":"207","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Biopharmaceutics and Drug Disposition"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"崔, 吉道"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Clenbuterol is a long-acting β2-adrenoceptor agonist and bronchodilator that is used for the treatment of asthma, but the desired activities reside almost exclusively in the (-)-R-enantiomer. This study examined enantioselectivity in the disposition of clenbuterol following administration of clenbuterol racemate to rats. Concentrations of clenbuterol enantiomers in plasma, urine and bile were determined by LC-MS/MS assay with a Chirobiotic T column. This method was confirmed to show high sensitivity, specificity and precision, and clenbuterol enantiomers in 0.1ml volumes of plasma were precisely quantified at concentrations as low as 0.25ng/ml. The pharmacokinetic profiles of clenbuterol enantiomers following intravenous and intraduodenal administration of clenbuterol racemate (2mg/kg) in rats were significantly different. The distribution volume of (-)-R-clenbuterol (9.17l/kg) was significantly higher than that of (+)-S-clenbuterol (4.14l/kg). The total body clearance of (-)-R-clenbuterol (13.5ml/min/kg) was significantly higher than that of the (+)-S-enantiomer (11.5ml/min/kg). An in situ absorption study in jejunal loops showed no difference in the residual amount between the (-)-R- and (+)-S-enantiomers. Urinary clearance was the same for the two enantiomers, but biliary excretion of (-)-R-clenbuterol was higher than that of the (+)-S-enantiomer. The fractions of free (non-protein-bound) (-)-R- and (+)-S-clenbuterol in rat plasma were 48.8% and 33.1%, respectively. These results indicated that there are differences in the distribution and excretion of the clenbuterol enantiomers, and these may be predominantly due to enantioselective protein binding. © 2013 John Wiley & Sons, Ltd.","subitem_description_type":"Abstract"}]},"item_4_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"発行後1年より全文公開","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00014970","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Wiley-Blackwell"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1002/bdd.1885","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00110161","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0142-2782","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hirosawa, Iori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishikawa, Mai"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogino, Mio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hirao, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamada, Harumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Asahi, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kotaki, Hajime"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sai, Yoshimichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Ken-ichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-SAI-Y-207.pdf","filesize":[{"value":"333.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-SAI-Y-207.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/14983/files/PH-PR-SAI-Y-207.pdf"},"version_id":"eca13490-34c7-470c-92ca-b149b072de40"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Enantioselective disposition of clenbuterol in rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Enantioselective disposition of clenbuterol in rats"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"14983","relation_version_is_last":true,"title":["Enantioselective disposition of clenbuterol in rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:51:24.297121+00:00"}