{"created":"2023-07-27T06:30:09.260672+00:00","id":15051,"links":{},"metadata":{"_buckets":{"deposit":"2c91abab-0d34-444b-b9f0-698267b1bd18"},"_deposit":{"created_by":3,"id":"15051","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15051"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015051","sets":["4281:4291:4312"]},"author_link":["27049","22615","22059","2702","86","27048","640","2604","27050","76677"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-07-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"7","bibliographicPageEnd":"1013","bibliographicPageStart":"1009","bibliographicVolumeNumber":"35","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石崎, 純子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"菅, 幸生"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"荒井, 國三"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"崔, 吉道"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Changes of mycophenolic acid (MPA) pharmacokinetics with aging were investigated in rats. We also compared the effect of concomitant amoxicillin/clavulanate combination (CVA/AMPC) on the pharmacokinetics of MPA in 4-week-old and 12-week-old rats (the package insert of CVA/AMPC warns of possible interaction with MPA). Four-week-old rats showed a 1.4-fold higher total body clearance of MPA and a lower volume of distribution of MPA (65%), compared to the values in 12-week-old rats. However, the difference in MPA pharmacokinetics disappeared when enterohepatic circulation was eliminated by bile duct cannulation (BDC). Concomitant CVA/AMPC significantly reduced plasma MPA concentration in intact rats of both age groups, and the age-dependent difference of MPA pharmacokinetics was no longer apparent. The effect of CVA/AMPC was not seen in rats that had undergone BDC, suggesting that the drug-drug interaction can be attributed to inhibition of enterohepatic circulation by CVA/AMPC. These results indicate that the aging-related alteration of MPA pharmacokinetics is a consequence of immature enterohepatic circulation in 4-week-old rats. Higher doses of MPA may be necessary in juveniles. © 2012 The Pharmaceutical Society of Japan.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00015038","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan = 日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.b110639","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/DN/JST.JSTAGE/bpb/b110639","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.pharm.or.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2012 The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishizaki, Junko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Tsuda, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suga, Yukio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Ito, Satsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Arai, Kunizo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Sai, Yoshimichi"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Ken-ichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-1009.pdf","filesize":[{"value":"624.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-1009.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15051/files/PH-PR-ISHIZAKI-J-1009.pdf"},"version_id":"0e4c8f56-7250-4106-b88b-a2588b285bc5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15051","relation_version_is_last":true,"title":["Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:51:20.895956+00:00"}