{"created":"2023-07-27T06:30:09.429423+00:00","id":15055,"links":{},"metadata":{"_buckets":{"deposit":"e217e330-9322-46c5-9b3f-334ce5bbcb4d"},"_deposit":{"created_by":3,"id":"15055","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15055"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015055","sets":["1132:1133:1135"]},"author_link":["27062","27061","27065","239","27064","27063"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1977-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"250","bibliographicPageStart":"244","bibliographicVolumeNumber":"97","bibliographic_titles":[{"bibliographic_title":"藥學雜誌"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The metabolic fate of ο-chloro-α-(tert-butylaminomethyl)-benzyl alcohol hydrochloride (C-78) in the rat was studied by oral administration of 14C-C-78, and the bronchodilating activities of the metabolites were also examined. The major metabolites in the urine, bile, and feces were unchanged C-78 (I) and 4-hydroxy- (II), 3-hydroxy- (III), and 4-hydroxy-5-methoxy-C-78 (IV), and their corresponding conjugates. As the minor metabolites, ο-chlorobenzoic acid, ο-chloromandelic acid, and 1-(ο-Chlorophenyl)-1, 2-ethanediol were detected by gas chromatography. These results suggested that the major metabolic pathway of C-78 in the rat is hydroxylation of the benzene ring. Although IV had no activity, II had a stronger bronchodilating activity than C-78, and III was as effective as C-78, suggesting the participation of the metabolites in the bronchodilating action and durability of C-78.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会 Pharmaceutical Society of Japan"}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110003652519/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.pharm.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.Journalarchive/yakushi1947/97.244","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/article/yakushi1947/97/3/97_3_244/_article/-char/ja/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山本, 譲"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"樋口, 昭平"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤橋, 俊明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"清水, 栄"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西出, 和憲"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上坂, 征夫"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-SHIMIZU-S-244.pdf","filesize":[{"value":"836.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMIZU-S-244.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15055/files/PH-PR-SHIMIZU-S-244.pdf"},"version_id":"81b3e16d-f20e-4e6c-881c-61737c59a4c8"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride(C-78)の生体内運命(第2報): ラットにおける代謝物","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride(C-78)の生体内運命(第2報): ラットにおける代謝物"},{"subitem_title":"The Metabolic Fate of ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride (C-78). II. Metabolic Products in the Rat","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15055","relation_version_is_last":true,"title":["ο-Chloro-α-(tert-butylaminomethyl)-benzyl Alcohol Hydrochloride(C-78)の生体内運命(第2報): ラットにおける代謝物"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:39:11.348198+00:00"}