{"created":"2023-07-27T06:30:10.451432+00:00","id":15080,"links":{},"metadata":{"_buckets":{"deposit":"5cd52c40-2486-4445-8f6f-51d2705d1eb6"},"_deposit":{"created_by":3,"id":"15080","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15080"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015080","sets":["1132:1133:1135"]},"author_link":["239","27130"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1990-09-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"9","bibliographicPageEnd":"2619","bibliographicPageStart":"2617","bibliographicVolumeNumber":"38","bibliographic_titles":[{"bibliographic_title":"Chemical & pharmaceutical bulletin"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The interaction of asterriquinone (ARQ), a novel antitumor agent isolated from Aspergillus fungi, with deoxyribonucleic acid (DNA), has been studied. The binding of ARQ in vitro with DNA (calf thymus) was ascertained by its behavior in gel filtration using a Sephadex G-25 column at pH 5.4. Some ARQ analogs having no, or less, antitumor activity did not exhibit any evidence of interaction with DNA under the same condition. From the results obtained in this work, the pK_a value of ARQs seemed to be critical between 6 and 7 for their binding to DNA and for exhibition of antitumor activity. Also, ARQ showed serious membrane deformations and an inhibitory effect on the membranous adenosine triphosphatase of Ehrlich carcinoma cells.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会 Pharmaceutical Society of Japan"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/cpb.38.2617","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110003628839/","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00602100","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0009-2363","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shimizu, Sakae"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Koshimura, Saburo"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-SHIMIZU-S-2617.pdf","filesize":[{"value":"465.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-SHIMIZU-S-2617.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15080/files/PH-PR-SHIMIZU-S-2617.pdf"},"version_id":"6f0f97d6-e652-4593-aa28-032ac66dff92"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Interaction of Asterriquinone with Deoxyribonucleic Acid in Vitro","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Interaction of Asterriquinone with Deoxyribonucleic Acid in Vitro"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15080","relation_version_is_last":true,"title":["Interaction of Asterriquinone with Deoxyribonucleic Acid in Vitro"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T11:17:18.028615+00:00"}