{"created":"2023-07-27T06:30:10.915001+00:00","id":15091,"links":{},"metadata":{"_buckets":{"deposit":"cef75dca-dd6d-4621-8192-095201b34961"},"_deposit":{"created_by":3,"id":"15091","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15091"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015091","sets":["4281:4291:4312"]},"author_link":["85909","71","27160","22059","76678","22233","83144","27161","77197","27049","113130","76675","640","568","27158","52683","235","27159","113129","45834","81164","86","24453","27050"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"219","bibliographicPageStart":"213","bibliographicVolumeNumber":"36","bibliographic_titles":[{"bibliographic_title":"医療薬学"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Satsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaki, Junko"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Koshibata, Mikie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Igarashi, Yasuro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Naoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Suga, Yukio"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nishimura, Ryosei"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Maeba, Hideaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Koizumi, Shoichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nakao, Shinji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sai, Yoshimichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Ken-ichi"}],"nameIdentifiers":[{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The purpose of this study was to investigate whether the trough plasma concentration of voriconazole (VRCZ) in the steady-state (Cmin) influences efficacy and safety in adult and pediatric patients. Treatment was successful in 75% of pediatric patients and 56% of adult patients,and there was no association between Cmin and efficacy.However,liver dysfunction occurred more frequently in the case that Cmin was over 4μg/mL in both adult and pediatric patients.Also,pediatric patients,especially those younger than 2 years,required a higher dose of VRCZ than adults to achieve a similar Cmin. We concluded that the use of VRCZ at a constant dose over a long period may lead to an increase in Cmin.Therefore,careful,continuous monitoring of the Cmin of VRCZ is necessary for pediatric patients,particularly recipients of hematopoietic stem cell transplantation.","subitem_description_type":"Abstract"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00015078","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本医療薬学会 = Japanese Society of Pharmaceutical Health Care and Sciences"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.5649/jjphcs.36.213","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.jstage.jst.go.jp/browse/jjphcs/36/4/_contents/-char/ja/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jsphcs.jp/","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright © 2010 日本医療薬学会 Japanese Society of Pharmaceutical Health Care and Sciences"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11527197","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-342X","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, さつき"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"石崎, 純子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"小柴, 美紀恵"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"五十嵐, 康郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"長田, 直人"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"菅, 幸生"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"西村, 良成"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"前馬, 秀明"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小泉, 晶一"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中尾, 眞二"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"横川, 弘一"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"崔, 吉道"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"宮本, 謙一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-ISHIZAKI-J-213.pdf","filesize":[{"value":"114.4 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-ISHIZAKI-J-213.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15091/files/PH-PR-ISHIZAKI-J-213.pdf"},"version_id":"1ccdf1ad-052d-4398-90ff-bcc68a0d84b0"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"小児と成人におけるボリコナゾールの血中濃度解析の比較","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"小児と成人におけるボリコナゾールの血中濃度解析の比較"},{"subitem_title":"Comparison of Relationship between Dosage and Serum Concentration of Voriconazole in Adult and Pediatric Patients","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["4312"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15091","relation_version_is_last":true,"title":["小児と成人におけるボリコナゾールの血中濃度解析の比較"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T08:51:32.102532+00:00"}