| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2017-10-04 |
| タイトル |
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|
タイトル |
Cigarette smoking substantially alters plasma microRNA profiles in healthy subjects |
| 言語 |
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|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| ID登録 |
|
|
ID登録 |
10.24517/00015087 |
|
ID登録タイプ |
JaLC |
| 著者 |
Takahashi, Kei
Yokota, Shin-ichi
Tatsumi, Naoyuki
Fukami, Tatsuki
Yokoi, Tsuyoshi
Nakajima, Miki
|
| 著者別表示 |
深見, 達基
横井, 毅
中嶋, 美紀
|
| 提供者所属 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
金沢大学ナノ生命科学研究所 / 金沢大学医薬保健研究域薬学系 |
| 書誌情報 |
Toxicology and Applied Pharmacology
巻 272,
号 1,
p. 154-160,
発行日 2013-10-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
0041-008X |
| NCID |
|
|
収録物識別子タイプ |
NCID |
|
収録物識別子 |
AA00864435 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
識別子タイプ |
DOI |
|
|
関連識別子 |
10.1016/j.taap.2013.05.018 |
| 出版者 |
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出版者 |
Elsevier |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
Circulating microRNAs (miRNAs) are receiving attention as potential biomarkers of various diseases, including cancers, chronic obstructive pulmonary disease, and cardiovascular disease. However, it is unknown whether the levels of circulating miRNAs in a healthy subject might vary with external factors in daily life. In this study, we investigated whether cigarette smoking, a habit that has spread throughout the world and is a risk factor for various diseases, affects plasma miRNA profiles. We determined the profiles of 11 smokers and 7 non-smokers by TaqMan MicroRNA array analysis. A larger number of miRNAs were detected in smokers than in non-smokers, and the plasma levels of two-thirds of the detected miRNAs (43 miRNAs) were significantly higher in smokers than in non-smokers. A principal component analysis of the plasma miRNA profiles clearly separated smokers and non-smokers. Twenty-four of the miRNAs were previously reported to be potential biomarkers of disease, suggesting the possibility that smoking status might interfere with the diagnosis of disease. Interestingly, we found that quitting smoking altered the plasma miRNA profiles to resemble those of non-smokers. These results suggested that the differences in the plasma miRNA profiles between smokers and non-smokers could be attributed to cigarette smoking. In addition, we found that an acute exposure of ex-smokers to cigarette smoke (smoking one cigarette) did not cause a dramatic change in the plasma miRNA profile. In conclusion, we found that repeated cigarette smoking substantially alters the plasma miRNA profile, interfering with the diagnosis of disease or signaling potential smoking-related diseases. © 2013 Elsevier Inc. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 関連URI |
|
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|
識別子タイプ |
URI |
|
|
関連識別子 |
http://www.elsevier.com/locate/issn/0041008X |
PH-PR-NAKAJIMA-M-154.pdf (426.3 kB)
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