@article{oai:kanazawa-u.repo.nii.ac.jp:00015105,
 author = {小川, 数馬 and Ogawa, Kazuma and Aoki, Miho},
 journal = {Scientific World Journal},
 month = {Jan},
 note = {Since apoptosis plays an important role in maintaining homeostasis and is associated with responses to therapy, molecular imaging of apoptotic cells could be useful for early detection of therapeutic effects, particularly in oncology. Radiolabeled annexin V compounds are the hallmark in apoptosis imaging in vivo. These compounds are reviewed from the genesis of apoptosis (cell death) imaging agents up to recent years. They have some disadvantages, including slow clearance and immunogenicity, because they are protein-based imaging agents. For this reason, several studies have been conducted in recent years to develop low molecule apoptosis imaging agents. In this review, radiolabeled phosphatidylserine targeted peptides, radiolabeled bis(zinc(II)-dipicolylamine) complex, radiolabeled 5-fluoropentyl-2-methyl-malonic acid (ML-10), caspase-3 activity imaging agents, radiolabeled duramycin, and radiolabeled phosphonium cation are reviewed as promising low-molecular-weight apoptosis imaging agents., 金沢大学新学術創成研究機構 / 金沢大学医薬保健研究域薬学系},
 title = {Radiolabeled apoptosis imaging agents for early detection of response to therapy},
 volume = {2014},
 year = {2014}
}