{"_buckets": {"deposit": "b1df0c77-d31f-44f9-8d54-4e88bcab8394"}, "_deposit": {"created_by": 3, "id": "15106", "owners": [3], "pid": {"revision_id": 0, "type": "depid", "value": "15106"}, "status": "published"}, "_oai": {"id": "oai:kanazawa-u.repo.nii.ac.jp:00015106", "sets": ["1135"]}, "author_link": ["27227", "3887", "27225", "29", "27226", "27224", "27223", "293"], "item_4_biblio_info_8": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2015-05-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "5", "bibliographicPageEnd": "780", "bibliographicPageStart": "774", "bibliographicVolumeNumber": "38", "bibliographic_titles": [{"bibliographic_title": "Biological and Pharmaceutical Bulletin"}]}]}, "item_4_description_21": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "5-Aminosalicylic acid (5-ASA) is an orally administered therapeutic agent for inflammatory bowel diseases, such as ulcerative colitis and Crohn’s disease. We hypothesized that the absorption of 5-ASA is mediated by the polyspecific carnitine/organic cation transporter (OCTN1/SLC22A4), based on the similarity of chemical structure between 5-ASA and other OCTN1 substrates. Therefore, we examined the involvement of this transporter in the disposition of 5-ASA in vivo by using octn1 gene knockout (octn1−/−) mice. After oral administration of 5-ASA, the plasma concentrations of 5-ASA and its primary metabolite, N-acetyl-5-aminosalicylate (Ac-5-ASA), in octn1−/− mice were much lower than those in wild-type mice. The time required to reach maximum plasma concentration was also delayed in octn1−/− mice. On the other hand, the plasma concentration profiles of both 5-ASA and Ac-5-ASA after intravenous administration of 5-ASA (bolus or infusion) were similar in the two strains. Uptake of 5-ASA from the apical to the basal side of isolated small-intestinal tissues of octn1−/− mice, determined in an Ussing-type chamber, was lower than that in wild-type mice. Further, uptake of 5-ASA in HEK293 cells stably transfected with the OCTN1 gene, assessed as the sum of cell-associated 5-ASA and Ac-5-ASA, was higher than that in HEK293 cells transfected with the vector alone. Overall, these results indicate that OCTN1 is involved, at least in part, in the gastrointestinal absorption of 5-ASA.", "subitem_description_type": "Abstract"}]}, "item_4_publisher_17": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Pharmaceutical Society of Japan = 日本薬学会"}]}, "item_4_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/bpb.b15-00109", "subitem_relation_type_select": "DOI"}}]}, "item_4_relation_28": {"attribute_name": "関連URI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.jstage.jst.go.jp/browse/bpb", "subitem_relation_type_select": "URI"}}, {"subitem_relation_type_id": {"subitem_relation_type_id_text": "http://www.pharm.or.jp/", "subitem_relation_type_select": "URI"}}]}, "item_4_rights_23": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright © 2015 The Pharmaceutical Society of Japan"}]}, "item_4_source_id_11": {"attribute_name": "NCID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10885497", "subitem_source_identifier_type": "NCID"}]}, "item_4_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0918-6158", "subitem_source_identifier_type": "ISSN"}]}, "item_4_version_type_25": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Shimizu, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "27223", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kijima, Ai"}], "nameIdentifiers": [{"nameIdentifier": "27224", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masuo, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "27225", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishimoto, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "27226", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sugiura, Tomoko"}], "nameIdentifiers": [{"nameIdentifier": "3887", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "70542190", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000070542190"}]}, {"creatorNames": [{"creatorName": "Takahashi, Saki"}], "nameIdentifiers": [{"nameIdentifier": "27227", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamichi, Noritaka"}], "nameIdentifiers": [{"nameIdentifier": "293", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "10401895", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=10401895"}, {"nameIdentifier": "10401895", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=10401895"}, {"nameIdentifier": "10401895", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000010401895"}]}, {"creatorNames": [{"creatorName": "Kato, Yukio"}], "nameIdentifiers": [{"nameIdentifier": "29", "nameIdentifierScheme": "WEKO"}, {"nameIdentifier": "30251440", "nameIdentifierScheme": "e-Rad", "nameIdentifierURI": "https://kaken.nii.ac.jp/ja/search/?qm=30251440"}, {"nameIdentifier": "30251440", "nameIdentifierScheme": "金沢大学研究者情報", "nameIdentifierURI": "http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30251440"}, {"nameIdentifier": "30251440", "nameIdentifierScheme": "研究者番号", "nameIdentifierURI": "https://nrid.nii.ac.jp/nrid/1000030251440"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2017-10-04"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "PH-PR-KATO-Y-774.pdf", "filesize": [{"value": "668.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 668300.0, "url": {"label": "PH-PR-KATO-Y-774.pdf", "url": "https://kanazawa-u.repo.nii.ac.jp/record/15106/files/PH-PR-KATO-Y-774.pdf"}, "version_id": "1347b3e4-7a30-4f85-a518-7fa23d967782"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "organic cation transporter", "subitem_subject_scheme": "Other"}, {"subitem_subject": "5-aminosalicylate", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gastrointestinal absorption", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Gene Ablation of Carnitine/Organic Cation Transporter 1 Reduces Gastrointestinal Absorption of 5-Aminosalicylate in Mice", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Gene Ablation of Carnitine/Organic Cation Transporter 1 Reduces Gastrointestinal Absorption of 5-Aminosalicylate in Mice"}]}, "item_type_id": "4", "owner": "3", "path": ["1135"], "permalink_uri": "http://hdl.handle.net/2297/43035", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-10-04"}, "publish_date": "2017-10-04", "publish_status": "0", "recid": "15106", "relation": {}, "relation_version_is_last": true, "title": ["Gene Ablation of Carnitine/Organic Cation Transporter 1 Reduces Gastrointestinal Absorption of 5-Aminosalicylate in Mice"], "weko_shared_id": -1}