@article{oai:kanazawa-u.repo.nii.ac.jp:00015139, author = {加野, 軒作 and 植竹, 厚子 and 清水, 栄 and 新田, 啓一 and 山本, 譲}, issue = {3}, journal = {藥學雜誌}, month = {Mar}, note = {Metabolism of 6-methyl-2-thiouracil was studied in rats by using ^<14>C-labeled compound. Following the oral administration of 6-methyl-2-thiouracil [2-^<14>C] (490 mg/kg), the about 68% of the administered radioactivity was excreted in urine, 27% in feces, and 1.2% in respiratory CO_2 within 72 hr. After oral ingestion of the radioactive compound, radioactive substances excreted in urine after 48 hr were 6-methyl-2-thiouracil, 6-methyl-uracil, 6-methyl-2-methylthiouracil, 6-methyl-4-oxo-pyrimidine, 2-amino-6-methyl-4-oxopyrimidine, and urea which were present in about 46.2,9.1,1.6,1.8,0.2,and 0.8% of total radioactivity in the urine, respectively. In in vitro tests using rat liver slices, radioactivity was also detected in 5,6-dihydro-6-methyluracil along with the above metabolites.}, pages = {332--337}, title = {2-Thio-6-methyluracilのラットにおける代謝について}, volume = {94}, year = {1974} }