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Effects of pH and Ligands on the Metals-Catalyzed Hydrolysis of Clioquinol Conjugates
http://hdl.handle.net/2297/44901
http://hdl.handle.net/2297/4490161f1911e-c805-4262-b612-b069cfc048cd
| 名前 / ファイル | ライセンス | アクション |
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PH-PR-HAYAKAWA-K-3205.pdf (547.0 kB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
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| 公開日 | 2017-10-04 | |||||
| タイトル | ||||||
| タイトル | Effects of pH and Ligands on the Metals-Catalyzed Hydrolysis of Clioquinol Conjugates | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Hayakawa, Kazuichi
× Hayakawa, Kazuichi× Wakatsuki, Misuzu× Yamada, Eiko× Shimizu, Kyoko× Kizu, Ryoichi× Miyazaki, Motoichi |
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| 書誌情報 |
Chemical and Pharmaceutical Bulletin 巻 32, 号 8, p. 3205-3209, 発行日 1984-01-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0009-2363 | |||||
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| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA00602100 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1248/cpb.32.3205 | |||||
| 出版者 | ||||||
| 出版者 | 日本薬学会 = The Pharmaceutical Society of Japan | |||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Metals-catalyzed hydrolysis of clioquinol (C) conjugates, namely C-glucuronide (CG) and C-sulfate (CS), was examined to investigate the effects of pH and ligands on the activities. The initial rates of hydrolysis (Vo) of CG and CS were measured as a function of pH in systems containing various metals. The profiles of Vo of CG varied from metal to metal, but the order of Vo in the acidic pH region was Cu (II) > Fe (III) > Ni (II) > Zn (II) > Mn (II), Mg (II), Ca (II). Acid hydrolysis of CG in the absence of metals was negligible down to pH 1. The profiles of Vo of CS were similar to that of acid hydrolysis in the absence of metals, except for the Cu (II) system, which gave a higher Vo. Under the condition [substrate] : [Cu (II)] : [ligand]=1 : 10 : 10, the hydrolysis in the presence of various ligands was a pseudo-first order reaction (rate constant=k'). All ligands which coordinate to Cu (II) reduced the value of k'. Such metals-catalyzed hydrolysis may be one of the mechanism of hydrolysis of C conjugates to produce C-metal chelates in vivo. | |||||
| 権利 | ||||||
| 権利情報 | Copyright © The Pharmaceutical Society of Japan | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 関連URI | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://www.pharm.or.jp/ | |||||
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| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/browse/cpb/-char/ja/ | |||||
