{"created":"2023-07-27T06:30:17.011630+00:00","id":15239,"links":{},"metadata":{"_buckets":{"deposit":"2827138b-c3d8-4ad5-b7b9-2378948386f1"},"_deposit":{"created_by":3,"id":"15239","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15239"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015239","sets":["1132:1133:1135"]},"author_link":["103","27298"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"12","bibliographicPageEnd":"1251","bibliographicPageStart":"1245","bibliographicVolumeNumber":"126","bibliographic_titles":[{"bibliographic_title":"藥學雜誌 = Journal of the Pharmaceutical Society of Japan"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Infection with a variety of viruses induces apoptosis in host cells. This phenomenon may be considered to be a self-defense mechanism to avoid viral propagation. However, the growth of influenza virus is completed before host cells become dysfunctional due to apoptosis. To clarify the physiologic consequences of influenza virus-induced apoptosis, the fate of influenza virus-infected cells was examined in vitro as well as in vivo. Influenza virus-infected cells were engulfed by macrophages in vitro, and virus propagation was almost completely inhibited. This phagocytosis was dependent on the specific recognition of the membrane phospholipid phosphatidylserine exposed on the surface of virus-infected apoptotic cells by macrophages. In addition, the activity of viral neuraminidase expressed at the surface of virus-infected cells was necessary for the maximal level of phagocytosis. When mice infected with influenza virus were administered phagocytosis inhibitors, the level of lethality and inflammation in the lung were augmented. These results show that apoptosis makes influenza virus-infected cells susceptible to phagocytosis by macrophages, and that this leads to a reduction in the extent of influenza pathology.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"日本薬学会 = The Pharmaceutical Society of Japan"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/yakushi.126.1245","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://ci.nii.ac.jp/naid/110004997528","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/yakushi/126.1245","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2006 by the PHARMACEUTICAL SOCIETY OF JAPAN"}]},"item_4_rights_24":{"attribute_name":"権利URI","attribute_value_mlt":[{"subitem_rights":"http://www.pharm.or.jp/"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00284903","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0031-6903","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白土, 明子"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中西, 義信"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-NAKANISHI-Y-1245.pdf","filesize":[{"value":"551.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANISHI-Y-1245.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15239/files/PH-PR-NAKANISHI-Y-1245.pdf"},"version_id":"fe8c4c90-4bbb-4d5a-9f6a-e05c850b0979"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"食細胞によるインフルエンザウイルス感染細胞の貪食除去(誌上シンポジウム)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"食細胞によるインフルエンザウイルス感染細胞の貪食除去(誌上シンポジウム)"},{"subitem_title":"Elimination of Influenza Virus-infected Cells by Phagocytosis(Symposium Review)","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15239","relation_version_is_last":true,"title":["食細胞によるインフルエンザウイルス感染細胞の貪食除去(誌上シンポジウム)"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:35:46.706786+00:00"}