@article{oai:kanazawa-u.repo.nii.ac.jp:00015258,
 author = {Motoyama, Yumi and Bekki, Kanae and Chung, Sang Woon and Tang, Ning and Kameda, Takayuki and Toriba, Akira and Taguchi, Keiko and Hayakawa, Kazuichi},
 issue = {5},
 journal = {Journal of Health Science = 衛生化学},
 month = {Oct},
 note = {The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2. ©2009 The Pharmaceutical Society of Japan.},
 pages = {845--850},
 title = {Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells},
 volume = {55},
 year = {2009}
}