{"created":"2023-07-27T06:30:17.814467+00:00","id":15258,"links":{},"metadata":{"_buckets":{"deposit":"0fc543a4-003e-41c8-ac7c-ba25dfd3ff05"},"_deposit":{"created_by":3,"id":"15258","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15258"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015258","sets":["1132:1133:1135"]},"author_link":["66","35","27588","27590","27589","27591","171","27592"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5","bibliographicPageEnd":"850","bibliographicPageStart":"845","bibliographicVolumeNumber":"55","bibliographic_titles":[{"bibliographic_title":"Journal of Health Science = 衛生化学"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The effect of four ortho-quinoid polycyclic aromatic hydrocarbons (PAHs) and seven para-quinoid PAHs on the viability of A549 cells were examined. The ortho-quinoid PAHs [1,2-naphthoquinone (1,2-NQ), 9,10-phenanthrenquinone (9,10-PQ), 5,6-chrysenequinone (5,6-CQ), and benzo[c]phenanthrene-5,6-quinone (B[c]P-5,6-Q)] overproduced hydrogen peroxide (H2O2) without being consumed themselves. These ortho-quinoid had strong cytotoxic effects except for 1,2-NQ, since of its tendency to covalently bind to thiol groups. The cytotoxicity appears to be due to the overproduction of H 2O2 by ortho-quinoid PAHs in a redox cycle coupled with the consumption of thiol group. In contrast, the para-quinoid PAHs were not as strong cytotoxic and did not produce H2O2. ©2009 The Pharmaceutical Society of Japan.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan = 日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/jhs.55.845","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.pharm.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/jhs/55.845","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2009 by The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Motoyama, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Bekki, Kanae"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chung, Sang Woon"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tang, Ning"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kameda, Takayuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Toriba, Akira"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Taguchi, Keiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Kazuichi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-HAYAKAWA-K-845.pdf","filesize":[{"value":"394.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-HAYAKAWA-K-845.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15258/files/PH-PR-HAYAKAWA-K-845.pdf"},"version_id":"6343d84e-fa38-4df2-b5cd-064cf5db08f5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15258","relation_version_is_last":true,"title":["Oxidative Stress More Strongly Induced by ortho- Than para-quinoid Polycyclic Aromatic Hydrocarbons in A549 Cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:35:24.415646+00:00"}