@article{oai:kanazawa-u.repo.nii.ac.jp:00015274,
 author = {Janvier, Katy and Kato, Yukio and Boehm, Markus and Rose, Jeremy R. and Martina, José A. and Kim, Bong-Yoon and Venkatesan, Sundararajan and Bonifacino, Juan S.},
 issue = {6},
 journal = {Journal of Cell Biology},
 month = {Dec},
 note = {The sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present in the cytosolic tails of the proteins. A subset of these signals conform to the [DE]XXXL[LI] consensus motif and mediate sorting via interactions with heterotetrameric adaptor protein (AP) complexes. However, the identity of the AP subunits that recognize these signals remains controversial. We have used a yeast three-hybrid assay to demonstrate that [DE]XXXL[LI]-type signals from the human immunodeficiency virus negative factor protein and the lysosomal integral membrane protein II interact with combinations of the γ and σ1 subunits of AP-1 and the δ and σ3 subunits of AP-3, but not the analogous combinations of AP-2 and AP-4 subunits. The sequence requirements for these interactions are similar to those for binding to the whole AP complexes in vitro and for function of the signals in vivo. These observations reveal a novel mode of recognition of sorting signals involving the γ/δ and σ subunits of AP-1 and AP-3., 金沢大学医薬保健研究域薬学系},
 pages = {1281--1290},
 title = {Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes},
 volume = {163},
 year = {2003}
}