{"created":"2023-07-27T06:30:18.454101+00:00","id":15274,"links":{},"metadata":{"_buckets":{"deposit":"88f607a8-26c1-426e-b292-7eecc463936a"},"_deposit":{"created_by":3,"id":"15274","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15274"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015274","sets":["1132:1133:1135"]},"author_link":["27633","27635","27630","27636","29","27631","27632","27634"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12-22","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"1290","bibliographicPageStart":"1281","bibliographicVolumeNumber":"163","bibliographic_titles":[{"bibliographic_title":"Journal of Cell Biology"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The sorting of transmembrane proteins to endosomes and lysosomes is mediated by signals present in the cytosolic tails of the proteins. A subset of these signals conform to the [DE]XXXL[LI] consensus motif and mediate sorting via interactions with heterotetrameric adaptor protein (AP) complexes. However, the identity of the AP subunits that recognize these signals remains controversial. We have used a yeast three-hybrid assay to demonstrate that [DE]XXXL[LI]-type signals from the human immunodeficiency virus negative factor protein and the lysosomal integral membrane protein II interact with combinations of the γ and σ1 subunits of AP-1 and the δ and σ3 subunits of AP-3, but not the analogous combinations of AP-2 and AP-4 subunits. The sequence requirements for these interactions are similar to those for binding to the whole AP complexes in vitro and for function of the signals in vivo. These observations reveal a novel mode of recognition of sorting signals involving the γ/δ and σ subunits of AP-1 and AP-3.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Rockefeller University Press"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1083/jcb.200307157","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00694812","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9525","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Janvier, Katy"}],"nameIdentifiers":[{"nameIdentifier":"27630","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Yukio"}],"nameIdentifiers":[{"nameIdentifier":"29","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30251440","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=30251440"},{"nameIdentifier":"30251440","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30251440"},{"nameIdentifier":"30251440","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030251440"}]},{"creatorNames":[{"creatorName":"Boehm, Markus"}],"nameIdentifiers":[{"nameIdentifier":"27631","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Rose, Jeremy R."}],"nameIdentifiers":[{"nameIdentifier":"27632","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Martina, José A."}],"nameIdentifiers":[{"nameIdentifier":"27633","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kim, Bong-Yoon"}],"nameIdentifiers":[{"nameIdentifier":"27634","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Venkatesan, Sundararajan"}],"nameIdentifiers":[{"nameIdentifier":"27635","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bonifacino, Juan S."}],"nameIdentifiers":[{"nameIdentifier":"27636","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-1281.pdf","filesize":[{"value":"451.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-1281.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15274/files/PH-PR-KATO-Y-1281.pdf"},"version_id":"a30d72e1-9349-4925-a7cf-4e05e3383338"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15274","relation_version_is_last":true,"title":["Recognition of dileucine-based sorting signals from HIV-1 Nef and LIMP-II by the AP-1 γ-σ1 and AP-3 δ-σ3 hemicomplexes"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-06-20T06:50:25.298299+00:00"}