{"created":"2023-07-27T06:30:18.747829+00:00","id":15281,"links":{},"metadata":{"_buckets":{"deposit":"97cc954e-08a4-466e-bd9d-bd5ab62168c6"},"_deposit":{"created_by":3,"id":"15281","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15281"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015281","sets":["1132:1133:1135"]},"author_link":["27661","21623","27660","27657","21465","27658","27659","29"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"208","bibliographicPageStart":"202","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"European Journal of Pharmaceutical Sciences"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Oligopeptide transporters are abundantly expressed in various types of cancer cells. We here synthesized two novel dipeptides, l-phenylalanyl sarcosine (Phe-Sar) and 4-(4-methoxyphenyl)-l-phenylalanyl sarcosine (Bip(OMe)-Sar), and examined their effect on the growth of human pancreatic cancer AsPC-1 cells, which are known to highly express oligopeptide transporter PEPT1/SLC15A1. Growth of AsPC-1 cells was inhibited by these two peptides and a typical PEPT1/SLC15A1 substrate Gly-Sar. Growth inhibition by Gly-Sar, Phe-Sar and Bip(OMe)-Sar was concentration-dependent with half-maximal inhibitory concentration of 50, 0.91 and 0.55mM, respectively. These peptides also inhibited PEPT1-mediated [3H]Gly-Sar uptake with half-maximal inhibitory concentration of 2.6, 0.81 and 0.27mM, respectively. Thus, the rank order of the tumor cell growth inhibition by these three peptides was the same as that of PEPT1-inhibitory activity. Growth of AsPC-1 cells was also inhibited by 2-aminobicyclo(2,2,1)heptane-2-carboxylic acid (BCH), which is a typical inhibitor of amino acid transporter system L. The growth inhibition by BCH and Gly-Sar was additive, suggesting that these compounds act at distinct loci. Oligopeptide transporters thus appear to be a promising target for inhibition of pancreatic cancer progression. These results also proposed the idea that oligopeptide transporter is required for growth of AsPC-1 cells. © 2010 Elsevier B.V.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier BV"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.ejps.2010.03.010","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10934504","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0928-0987","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mitsuoka, Keisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Yukio"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Miyoshi, Sosuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Murakami, Yoshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hiraiwa, Mariko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kubo, Yoshiyuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Nishimura, Shintaro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuji, Akira"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-KATO-Y-202.pdf","filesize":[{"value":"406.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-KATO-Y-202.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15281/files/PH-PR-KATO-Y-202.pdf"},"version_id":"3b7a27e4-306b-4aa3-af9f-453f39ec8c45"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15281","relation_version_is_last":true,"title":["Inhibition of oligopeptide transporter suppress growth of human pancreatic cancer cells"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:35:00.728298+00:00"}