{"created":"2023-07-27T06:30:18.831932+00:00","id":15283,"links":{},"metadata":{"_buckets":{"deposit":"6fa195ba-8dd2-4e0d-9cf8-266fcdbeb6df"},"_deposit":{"created_by":3,"id":"15283","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15283"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015283","sets":["1132:1133:1135"]},"author_link":["102"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-10-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"10","bibliographicPageEnd":"1437","bibliographicPageStart":"1428","bibliographicVolumeNumber":"101","bibliographic_titles":[{"bibliographic_title":"Journal of inorganic biochemistry"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Cu in blood has been believed to transport into cell via albumin and some amino acids. To shed light on the Cu transport process we studied the reaction of the Cu(II)-peptide with the amino acid by absorption and CD spectra. Albumin mimic peptides GlyGly-l-HisGly (GGHG) and penta-Gly(G5) formed stable 4N coordinated Cu(II) complexes, but in the reaction with histidine (His) and penicillamine (Pes) the ternary Cu(II) complex formations were observed different by the kinetic study. Cu(II)-G5 complexes reacted with Pes to form the ternary complex Cu(H-1G5)(Pes-) which was subsequently transformed to the binary complex Cu(Pes-)2. In the system with GGHG the Cu(II) was also transported from GGHG to Pes, but the ternary Cu(H-1GGHG)(Pes-) complex as the intermediate was detected a trace. The ternary complex would be spontaneously transformed to Cu(Pes-)2 upon forming, because the rate constant of the ternary complex formation k1+ = ∼2 M-1 s-1 was less than k2+ = ∼5 × 102 M-1 s-1 for the Cu(Pes-)2 formation at physiological pH. In the Cu(II)-GGHG-His system the ternary Cu(H-1GGHG)(His) complex was also hardly identified because the formation constant K1 and k1+ were very small and the equilibrium existed between Cu(H-2GGHG) and Cu(His)2 and its overall equilibrium constant β2 for Cu(His)2 was very small to be 1.00 ± 0.05 M-1 at pH 9.0. These results indicated that the ternary complex is formed in the Cu transport process from the albumin to the amino acid, but His imidazole nitrogen in the fourth-binding site of Cu(II) strongly resists the replacement by the incoming ligand. © 2007 Elsevier Inc. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"医薬保健研究域　薬学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jinorgbio.2007.05.014","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00258264","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0162-0134","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小谷, 明"},{"creatorName":"オダニ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-ODANI-A-1428.pdf","filesize":[{"value":"863.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-ODANI-A-1428.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15283/files/PH-PR-ODANI-A-1428.pdf"},"version_id":"44983374-d37d-4a35-9b47-49cbfb5d8fd5"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Transport of Cu(II) from an Albumin Mimic Peptide, GlyGlyHisGly, to Histidine and Penicillamin.","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Transport of Cu(II) from an Albumin Mimic Peptide, GlyGlyHisGly, to Histidine and Penicillamin."}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15283","relation_version_is_last":true,"title":["Transport of Cu(II) from an Albumin Mimic Peptide, GlyGlyHisGly, to Histidine and Penicillamin."],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:34:58.928630+00:00"}