@article{oai:kanazawa-u.repo.nii.ac.jp:00015284,
 author = {Ohno, Takanori and Toriba, Akira and Kameda, Takayuki and Tang, Ning and Hayakawa, Kazuichi},
 issue = {21},
 journal = {Journal of Chromatography A},
 month = {May},
 note = {To measure the actual exposure of a person to 1-nitropyrene (1-NP) in airborne particulate matter, it is considered more accurate to collect air samples with a portable air sampler than to sample at a fixed location. However, because the portable samplers can sample only small volumes, a sensitive method is needed to analyze the compounds that are collected on a filter. Here we describe a high-performance liquid chromatographic (HPLC) method with fluorescence detection that is sensitive and precise enough for use with portable air samplers. The developed column-switching system successfully removed the interfering substances in the samples with only a simple pretreatment. To improve the precision of the measurement, deuterated 1-NP was used as an internal standard, and it eluted immediately prior to 1-NP with sufficient resolution (Rs, 1.50). The detection limit was 0.32 fmol/injection, and the calibration range was from 2 to 100 fmol. The proposed method was applied to determining 1-NP in fine airborne particulate matter (PM2.5) at two sites with low pollution levels. 1-NP was detected in all samples at concentrations in the low fmol/m3 range. The proposed method has enough sensitivity and precision to determine 1-NP in the limited air volume of the portable sampler. © 2009 Elsevier B.V. All rights reserved., 金沢大学医薬保健研究域薬学系},
 pages = {4625--4628},
 title = {Determination of 1-nitropyrene in low volume ambient air samples by high-performance liquid chromatography with fluorescence detection},
 volume = {1216},
 year = {2009}
}