{"created":"2023-07-27T06:30:19.127439+00:00","id":15290,"links":{},"metadata":{"_buckets":{"deposit":"abbdb8d5-6035-4e9c-8521-ab3ea7ec15f9"},"_deposit":{"created_by":3,"id":"15290","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15290"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015290","sets":["1132:1133:1135"]},"author_link":["27688","27687","522","103","27691","27298","27693","27690","27694","27686","95410","27684","27683","27689","27692","27685"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"3878","bibliographicPageStart":"3868","bibliographicVolumeNumber":"28","bibliographic_titles":[{"bibliographic_title":"EMBO Journal"}]}]},"item_4_creator_33":{"attribute_name":"著者別表示","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"永長, 一茂"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"中西, 義信"}],"nameIdentifiers":[{},{},{},{}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Phagocytic removal of cells undergoing apoptosis is necessary for animal development and tissue homeostasis. Draper, a homologue of the Caenorhabditis elegans phagocytosis receptor CED-1, is responsible for the phagocytosis of apoptotic cells in Drosophila, but its ligand presumably present on apoptotic cells remains unknown. An endoplasmic reticulum protein that binds to the extracellular region of Draper was isolated. Loss of this protein, which we name Pretaporter, led to a reduced level of apoptotic cell clearance in embryos, and the overexpression of pretaporter in the mutant flies rescued this defect. Results from genetic analyses suggested that Pretaporter functionally interacts with Draper and the corresponding signal mediators. Pretaporter was exposed at the cell surface after the induction of apoptosis, and cells artificially expressing Pretaporter at their surface became susceptible to Draper-mediated phagocytosis. Finally, the incubation with Pretaporter augmented the tyrosine-phosphorylation of Draper in phagocytic cells. These results collectively suggest that Pretaporter relocates from the endoplasmic reticulum to the cell surface during apoptosis to serve as a ligand for Draper in the phagocytosis of apoptotic cells. © 2009 European Molecular Biology Organization.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_4_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.24517/00015277","subitem_identifier_reg_type":"JaLC"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Nature Publishing Group"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/emboj.2009.343","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10627582","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0261-4189","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kuraishi, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakagawa, Yukiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagaosa, Kazushige"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Hashimoto, Yumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishimoto, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moki, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Yu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakayama, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Dohmae, Naoshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shiratsuchi, Akiko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Nakako"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ueda, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamagichi, Masamitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Awasaki, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakanishi, Yoshinobu"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-NAKANISHI-Y-3868.pdf","filesize":[{"value":"10.5 MB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"PH-PR-NAKANISHI-Y-3868.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15290/files/PH-PR-NAKANISHI-Y-3868.pdf"},"version_id":"6c367ded-2cfc-4fe0-88b9-ab01cbdb00e6"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15290","relation_version_is_last":true,"title":["Pretaporter, a Drosophila protein serving as a ligand for Draper in the phagocytosis of apoptotic cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-27T10:56:15.791065+00:00"}