{"created":"2023-07-27T06:30:21.821622+00:00","id":15355,"links":{},"metadata":{"_buckets":{"deposit":"3a23c8d2-3aa7-43c2-94fb-bf5202b4e6c4"},"_deposit":{"created_by":3,"id":"15355","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15355"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015355","sets":["1132:1133:1135"]},"author_link":["27049","22615","22233","22059","27868","640","27866","27867","27865","27869"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-01-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"99","bibliographicPageStart":"95","bibliographicVolumeNumber":"33","bibliographic_titles":[{"bibliographic_title":"Biological and Pharmaceutical Bulletin"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the binding of various basic drugs to the F1S and A genetic variants of α1-acid glycoprotein (AGP), which were isolated from native human commercial AGP (total AGP) by chromatography on an immobilized copper(II) affinity adsorbent. The values of the dissociation constant (Kd) of some basic drugs with the F1S variant in equilibrium dialysis differed characteristically from those with the A variant. The selective binding to these variants was evaluated by measuring the displacement ratio of dicumarol bound to the F1S variant or that of acridine orange bound to the A variant, using circular dichroism spectroscopy. There was reasonably good agreement between the Kd values and displacement ratios. There was a characteristic difference between the values of inhibition constant (Ki) of basic drugs towards dipyridamole binding to F1S and towards disopyramide binding to A in total AGP. We found that the Ki values for dipyridamole binding were well correlated with the Kd values for the F1S variant, whereas those for disopyramide binding were well correlated with the Kd values for the A variant. In conclusion, the higher the affinity of basic drugs for AGP, the more they inhibit the binding of other basic drugs, and further, the inhibitory potency depends on the selectivity of binding to the AGP variants. © 2010 Pharmaceutical Society of Japan.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan = 日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/bpb.33.95","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.jstage.jst.go.jp/article/bpb/33/1/33_95/_article","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(c) 2010 The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA10885497","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0918-6158","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishizaki, Junko"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Fukaishi, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuwa, Chie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamazaki, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tabata, Mayu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishida, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suga, Yukio"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Arai, Kunizo"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Yokogawa, Koichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Miyamoto, Kenichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-ISIZAKI-J-95.pdf","filesize":[{"value":"201.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-ISIZAKI-J-95.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15355/files/PH-PR-ISIZAKI-J-95.pdf"},"version_id":"a231c255-af46-42d4-99bb-85caf487fa73"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of selective competitive binding of basic drugs to α1-acid glycoprotein variants","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of selective competitive binding of basic drugs to α1-acid glycoprotein variants"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15355","relation_version_is_last":true,"title":["Evaluation of selective competitive binding of basic drugs to α1-acid glycoprotein variants"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:33:49.111161+00:00"}