@article{oai:kanazawa-u.repo.nii.ac.jp:00015360, author = {早川, 和一 and 鳥羽, 陽 and 亀田, 貴之 and 唐, 寧}, issue = {11}, journal = {分析化学 = Japan analyst}, month = {Nov}, note = {化石燃料の消費量の増加は,大気中に大量の汚染物質を排出し,深刻な健康影響を招いている。有害大気汚染物質の一つに多環芳香族炭化水素(PAH)とニトロ多環芳香族炭化水素(NPAH)がある.このうち,NPAHは極めて強い変異原性を有するものがあるにもかかわらず,環境中の濃度はPAHよりはるかに低く,しかもNPAHを追跡できる高感度な分析法もなかったため,PAHに比較するとNPAHの環境動態や健康影響に関する研究は大きく立ち遅れていた.本総説では,1980年代の後半から始まった高感度なNPAH分析法の開発研究を解説し,更にそれを用いて急速に展開しているNPAHの発生と大気内動態の解析,並びにヒト暴露測定について最近の動向までを解説する. With an increase in the consumption of fossil fuels, large amounts of pollutants released into the atmosphere cause serious health problems. Polycyclic aromatic hydrocarbons (PAHs) and nitropolycyclic aromatic hydrocarbons (NPAHs) are among the atmospheric hazardous pollutants. The mutagenicities of several NPAHs are much stronger than those of PAHs, but the concentrations of NPAHs are much lower than those of PAHs in the environment. However, the progress of studies on the environmental behaviors and health effects of NPAHs has been much slower than that of PAHs, because of the lack of a sensitive analytical method available for trace NPAHs. This review deals with the development of sensitive determination methods for NPAHs starting the in late 1980s and recent studies on the contributors and atmospheric behaviors of NPAHs and human exposure to them., 金沢大学医薬保健研究域薬学系, 金沢大学医薬保健研究域薬学系}, pages = {905--920}, title = {有害性ニトロ多環芳香族炭化水素類を対象とする分析法の開発と環境動態解析}, volume = {56}, year = {2007} }