@article{oai:kanazawa-u.repo.nii.ac.jp:00015362,
 author = {Ando, Yoshiaki and Yasuoka, Chika and Mishima, Takuya and Ikematsu, Takuya and Uede, Toshimitsu and Matsunaga, Tsukasa and Inobe, Manabu},
 issue = {4},
 journal = {In Vitro Cellular and Developmental Biology - Animal},
 month = {Apr},
 note = {T cell activation is regulated by two distinct signals, signals one and two. Concanavalin A (ConA) is an antigen-independent mitogen and functions as signal one inducer, leading T cells to polyclonal proliferation. CD28 is known to be one of major costimulatory receptors and to provide signal two in the ConA-induced T cell proliferation. Here, we have studied the implication of other costimulatory pathways in the ConA-mediated T cell proliferation by using soluble recombinant proteins consisting of an extracellular domain of costimulatory receptors and Fc portion of human IgG. We found that T cell proliferation induced by ConA, but not PMA plus ionomycin or anti-CD3 mAb, is significantly inhibited by herpes virus entry mediator (HVEM)-Ig, even in the presence of CD28 signaling. Moreover, the high concentration of HVEM-Ig molecules almost completely suppressed ConA-mediated T cell proliferation. These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation. © 2013 The Society for In Vitro Biology.},
 pages = {313--320},
 title = {Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule},
 volume = {50},
 year = {2014}
}