{"created":"2023-07-27T06:30:22.115540+00:00","id":15362,"links":{},"metadata":{"_buckets":{"deposit":"8bb649af-e4cb-4f84-91ee-fa13ed21f418"},"_deposit":{"created_by":3,"id":"15362","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15362"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015362","sets":["1132:1133:1135"]},"author_link":["27899","27896","27090","27898","53","27897","27895"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-04-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"320","bibliographicPageStart":"313","bibliographicVolumeNumber":"50","bibliographic_titles":[{"bibliographic_title":"In Vitro Cellular and Developmental Biology - Animal"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"T cell activation is regulated by two distinct signals, signals one and two. Concanavalin A (ConA) is an antigen-independent mitogen and functions as signal one inducer, leading T cells to polyclonal proliferation. CD28 is known to be one of major costimulatory receptors and to provide signal two in the ConA-induced T cell proliferation. Here, we have studied the implication of other costimulatory pathways in the ConA-mediated T cell proliferation by using soluble recombinant proteins consisting of an extracellular domain of costimulatory receptors and Fc portion of human IgG. We found that T cell proliferation induced by ConA, but not PMA plus ionomycin or anti-CD3 mAb, is significantly inhibited by herpes virus entry mediator (HVEM)-Ig, even in the presence of CD28 signaling. Moreover, the high concentration of HVEM-Ig molecules almost completely suppressed ConA-mediated T cell proliferation. These results suggest that HVEM might play more important roles than CD28 in ConA-mediated T cell proliferation. © 2013 The Society for In Vitro Biology.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Society for In-Vitro Biology / Springer Verlag (Germany)"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1007/s11626-013-9705-2","subitem_relation_type_select":"DOI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11003480","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1071-2690","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ando, Yoshiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yasuoka, Chika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mishima, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ikematsu, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Uede, Toshimitsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsunaga, Tsukasa"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Inobe, Manabu"}],"nameIdentifiers":[{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-INOBE-M-313author.pdf","filesize":[{"value":"817.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-INOBE-M-313author.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15362/files/PH-PR-INOBE-M-313author.pdf"},"version_id":"ff69b1a0-b093-48cb-87a4-4bcb52802ae1"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15362","relation_version_is_last":true,"title":["Concanavalin A-mediated T cell proliferation is regulated by herpes virus entry mediator costimulatory molecule"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:33:44.978124+00:00"}