{"created":"2023-07-27T06:30:23.248579+00:00","id":15389,"links":{},"metadata":{"_buckets":{"deposit":"be47594d-78f1-4128-938a-d28647ce8e13"},"_deposit":{"created_by":3,"id":"15389","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15389"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015389","sets":["1132:1133:1135"]},"author_link":["27986","27989","27988","66","35","27987","171"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"122","bibliographicPageStart":"118","bibliographicVolumeNumber":"54","bibliographic_titles":[{"bibliographic_title":"Journal of Health Science = 衛生化学"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Endocrine disrupting activities of three isomers of monohydroxylated 1-nitropyrene (1-NP) [3-, 6-, and 8-hydroxy-1-nitropyrenes (OHNPs)] were evaluated for the first time by yeast two-hybrid assay. OHNPs, which are not only metabolites of 1-NP but are also found in airborne particles, did not exhibit androgenic activity but exhibited estrogenic, antiestrogenic, and antiandrogenic activities. 6-OHNP showed the strongest estrogenic activity among the three OHNP isomers examined in this study. Concentrations of the OHNP isomers that gave 10% of activity of 1.0 × 10-6 M 17β-estradiol (E2) were as follows: 3-OHNP, 6.0 × 10 -7 M; 6-OHNP, 6.0 × 10-8 M; 8-OHNP, 9.0 × 10-7 M. On the contrary, 8-OHNP exhibited the strongest antiestrogenic and antiandrogenic activities of the three isomers. 1.0 × 10-6 M of 8-OHNP inhibited 32 and 90% of β-galactosidase activity induced by 1.0 × 10-9 M of E2 and 1.0 × 10-8 M of 5α-dihydrotestosterone (DHT), respectively. These findings point out the necessity for detailed investigation of environmental sources and distributions of OHNPs as well as the parent 1-NP.","subitem_description_type":"Abstract"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Pharmaceutical Society of Japan = 日本薬学会"}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isIdenticalTo","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1248/jhs.54.118","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.pharm.or.jp/","subitem_relation_type_select":"URI"}},{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://japanlinkcenter.org/JST.JSTAGE/jhs/54.118","subitem_relation_type_select":"URI"}}]},"item_4_rights_23":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"Copyright (c) 2008 by The Pharmaceutical Society of Japan"}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11316464","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1344-9702","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kameda, Takayuki"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Akiyama, Ayuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toriba, Akira"}],"nameIdentifiers":[{},{},{},{}]},{"creatorNames":[{"creatorName":"Tachikawa, Chihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshita, Morio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tang, Ning"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakawa, Kazuichi"}],"nameIdentifiers":[{},{},{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"PH-PR-KAMEDA-T-118.pdf","filesize":[{"value":"220.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"PH-PR-KAMEDA-T-118.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15389/files/PH-PR-KAMEDA-T-118.pdf"},"version_id":"60af4350-fa97-4054-833d-1fe7b1809789"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Evaluation of Endocrine Disrupting Activities of Monohydroxylated Derivatives of 1-nitropyrene by Yeast Two-hybrid Assay","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Evaluation of Endocrine Disrupting Activities of Monohydroxylated Derivatives of 1-nitropyrene by Yeast Two-hybrid Assay"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15389","relation_version_is_last":true,"title":["Evaluation of Endocrine Disrupting Activities of Monohydroxylated Derivatives of 1-nitropyrene by Yeast Two-hybrid Assay"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:33:15.608804+00:00"}