{"created":"2023-07-27T06:30:23.583916+00:00","id":15397,"links":{},"metadata":{"_buckets":{"deposit":"856a7e3c-2090-4e54-877a-ecf91e1ecd2f"},"_deposit":{"created_by":3,"id":"15397","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"15397"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00015397","sets":["1132:1133:1135"]},"author_link":["28010","27221","28016","28015","28014","28011","28013","28012"],"item_4_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-11-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1-3","bibliographicPageEnd":"452","bibliographicPageStart":"448","bibliographicVolumeNumber":"134","bibliographic_titles":[{"bibliographic_title":"Journal of Affective Disorders"}]}]},"item_4_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: To study the association between lipid-metabolism and depressive symptoms, genetic polymorphisms in serotonin transporter linked promoter region (5-HTTLPR) and fatty acid synthase gene (FASN) were investigated. Method: A cross-sectional study was conducted on 177 women (n = 166) and men (n = 15) recruited from workers in a hospital and nursing homes in Japan. Depressive symptoms were assessed by the Center for Epidemiologic Studies Depression (CES-D) scale and perceived psychological stress was measured using visual analogue scale (VAS). The genotypes of 5-HTTLPR (insertion/deletion; L/S), and FASN (Val1483Ile) were determined by the PCR methods. Linear regression analysis was performed, in which CES-D scores served as a dependent variable, and VAS scores, gene polymorphism, and confounders as independent variables. Results: Under the influence of perceived stress, S/S carriers of the 5-HTTLPR gene showed significantly higher CES-D scores in comparison with L/L + L/S carriers (F = 8.2, standardised β = 0.15, p < 0.05). Regression analysis also confirmed that CES-D scores in participants with Ile/Ile + Val/Ile genotypes of the FASN gene were significantly higher than those with Val/Val genotype (F = 8.4, standardised β = 0.16, p < 0.05). In relation to physical features, BMI among participants with S/S genotype of 5-HTTLPR was significantly lower compared with those with L/L + L/S genotypes. Conclusions: The Val1483Ile polymorphism in the FASN was associated with depressive symptoms under the influence of psychological stress. The S variant of 5-HTTLPR was related with less obese. © 2011 Elsevier B.V. All rights reserved.","subitem_description_type":"Abstract"}]},"item_4_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医薬保健研究域薬学系","subitem_description_type":"Other"}]},"item_4_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier B.V."}]},"item_4_relation_12":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.jad.2011.05.010","subitem_relation_type_select":"DOI"}}]},"item_4_relation_28":{"attribute_name":"関連URI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://www.elsevier.com/locate/issn/01650327","subitem_relation_type_select":"URI"}}]},"item_4_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA00256633","subitem_source_identifier_type":"NCID"}]},"item_4_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0165-0327","subitem_source_identifier_type":"ISSN"}]},"item_4_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tsuboi, Hirohito"}],"nameIdentifiers":[{},{},{}]},{"creatorNames":[{"creatorName":"Sakakibara, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamakawa-Kobayashi, Kimiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tatsumi, Asami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Inamori, Tomoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hamamoto, Reiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suzuki, Atsuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimoi, Kayoko"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"ME-PR-TSUBOI-H-448.pdf","filesize":[{"value":"216.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"ME-PR-TSUBOI-H-448.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/15397/files/ME-PR-TSUBOI-H-448.pdf"},"version_id":"619ac7ed-539c-484e-985a-a83332149019"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress"}]},"item_type_id":"4","owner":"3","path":["1135"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"15397","relation_version_is_last":true,"title":["Val1483Ile polymorphism in the fatty acid synthase gene was associated with depressive symptoms under the influence of psychological stress"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:33:03.500195+00:00"}