@article{oai:kanazawa-u.repo.nii.ac.jp:00015404,
 author = {Sasaki, Hideki and Yonekubo, Jun and Hayakawa, Kazuichi},
 issue = {6},
 journal = {Analytical Sciences},
 month = {Jan},
 note = {Current on-line solid-phase extraction methods combined with HPLC for shortening the clean-up operation are not suitable for simultaneously detecting compounds that have a wide variety of hydrophobicities. To solve these problems, we designed a new on-line sample preparation system. The system consists of an eluting pump, a mixing TEE connector, a 10-port 2-position valve and a solid-phase extraction precolumn. The eluate from the precolumn is diluted with a weak solvent from the HPLC at the TEE connection to load low hydrophobic compounds onto the analytical column. The proposed on-line sample preparation system was successfully applied to the simultaneous analysis of 21 pesticides in river water using LC/TOF-MS. In this method, the recoveries from river water samples were 67 to 126% (mean 83%), the reproducibility (CV%) was in the range from 1.1 to 11% (mean 5.6%), the calibration curve was linear in the range from 1 ppb to 500 ppb (r > 0.999) and the detection limits (S/N = 3) were in the range from 0.0034 ppb (daimuron) to 3.3 ppb (oxine-copper). 2006 © The Japan Society for Analytical Chemistry.},
 pages = {835--840},
 title = {A new on-line sample preparation system for the liquid chromatography/time- of-flight mass spectrometry simultaneous analysis of pesticides in river water},
 volume = {22},
 year = {2006}
}