{"created":"2023-07-27T06:30:52.725490+00:00","id":16081,"links":{},"metadata":{"_buckets":{"deposit":"bd308797-598e-4d82-a58a-cf27747d6e45"},"_deposit":{"created_by":3,"id":"16081","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"16081"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00016081","sets":["1132:1137:1223:1226"]},"author_link":["22657","323","661"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-01-27","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"94","bibliographicPageStart":"85","bibliographicVolumeNumber":"39","bibliographic_titles":[{"bibliographic_title":"金沢大学つるま保健学会誌 = Journal of the Tsuruma Health Science Society, Kanazawa University"}]}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The role of hepatocyte growth factor （HGF）-induced activation （phosphorylation） of its receptor, c-Met, and subsequent downstream signaling during muscle regeneration has not yet been adequately determined. We examined HGF and phospho-c-Met expression and localization during the expansion phase and time course of satellite cell activation, which is critical for muscle regeneration after injury. HGF, c-Met, myogenic differentiation 1 （MyoD）, and myogenin mRNA levels were significantly increased during muscle regeneration after injury. Phospho-c-Met was localized on the surface of regenerating muscle cells. HGF was colocalized in the same cells as phospho-c-Met, MyoD, or myogenin. The muscle area occupied by HGF-, phospho-c-Met-, MyoD-, or myogenin-positive cells expanded along with expansion of regenerating muscle. Thus, c-Met is expressed in regenerating muscle cells immediately after injury, and its kinase activity is likely activated by HGF expressed by the same cells, suggesting that HGF and c-Met contribute to myogenesis in vivo.","subitem_description_type":"Abstract"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学つるま保健学会 = Tsuruma Health Science Society, Kanazawa University"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AA11599711","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-8502","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 正二"}],"nameIdentifiers":[{"nameIdentifier":"323","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70422657","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=70422657"},{"nameIdentifier":"70422657","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=70422657"},{"nameIdentifier":"70422657","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000070422657"}]},{"creatorNames":[{"creatorName":"河原, 榮"}],"nameIdentifiers":[{"nameIdentifier":"661","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90161348","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90161348"},{"nameIdentifier":"90161348","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090161348"}]},{"creatorNames":[{"creatorName":"中川, 敬夫"}],"nameIdentifiers":[{"nameIdentifier":"22657","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40217675","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=40217675"},{"nameIdentifier":"40217675","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000040217675"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AA11599711-39-2-85-94.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA11599711-39-2-85-94.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/16081/files/AA11599711-39-2-85-94.pdf"},"version_id":"5ce1e37a-6b38-45f2-8d3f-80200a0e2bed"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"skeletal muscle regeneration","subitem_subject_scheme":"Other"},{"subitem_subject":"hepatocyte growth factor","subitem_subject_scheme":"Other"},{"subitem_subject":"satellite cell","subitem_subject_scheme":"Other"},{"subitem_subject":"c-Met","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝細胞増殖因子の発現は骨格筋再生領域の拡大と同期する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞増殖因子の発現は骨格筋再生領域の拡大と同期する"},{"subitem_title":"Expression of hepatocyte growth factor is synchronized with expansion of myogenesis in regenerating skeletal muscle","subitem_title_language":"en"}]},"item_type_id":"7","owner":"3","path":["1226"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"16081","relation_version_is_last":true,"title":["肝細胞増殖因子の発現は骨格筋再生領域の拡大と同期する"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:22:05.966958+00:00"}