{"created":"2023-07-27T06:31:37.045057+00:00","id":17104,"links":{},"metadata":{"_buckets":{"deposit":"8e4ebf45-4ae9-4114-ba26-f5d0ac85c50d"},"_deposit":{"created_by":3,"id":"17104","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17104"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017104","sets":["1132:1137:1270:1316"]},"author_link":["30811"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3･4","bibliographicPageEnd":"116","bibliographicPageStart":"109","bibliographicVolumeNumber":"113","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2005202413","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"コンベンショナル環境下でアトピー性皮膚炎(AD)を発症したNC/Ngaマウス(コンベンショナル群)とSPF環境下でADを発症しないNC/Ngaマウス(SPF群)を用い,一酸化窒素(NO)やNOより生じる活性窒素種(RNS)とAD病態との関係を検討した.コンベンショナル群の皮膚病変部において誘導型NO合成酵素(NOS)および内皮型NOS発現はSPF群より有意に上昇し,神経型NOSの発現は減少傾向を示した.また,コンベンショナル群の血清中の亜硝酸イオンおよび硝酸イオン濃度はSPF群より有意に上昇したが,皮膚中での濃度は有意に低下していた.AD様皮膚病変部ではニトロチロシンやS-ニトロソチオール量が有意に増加し,ニトロチロシンの産生は好酸球に認められた.一方,酸化ストレス指標であるthiobarbituric acid-reactive substancesや8-ヒドロキシデオキシグアノシンの生成は両群間で有意差を認めなかった.NC/NgaマウスではAD皮膚病変部におけるNOSアイソフォームの発現の変化,NOxの減少やRNS産生の増加などNO代謝バランスの変化がAD病態と関連していると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科環境医科学専攻環境生態医学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久保, 正幸"}],"nameIdentifiers":[{"nameIdentifier":"30811","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-018-kubo.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-018-kubo.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17104/files/C0000002237-018-kubo.pdf"},"version_id":"b506ce68-28ed-4508-badb-b1e100cec551"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"IgE","subitem_subject_scheme":"Other"},{"subitem_subject":"酵素遺伝子発現調節","subitem_subject_scheme":"Other"},{"subitem_subject":"疾患モデル(動物)","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚炎-アトピー性(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"Nitric Oxide Synthase","subitem_subject_scheme":"Other"},{"subitem_subject":"Thiobarbituric Acid Reactive Substances","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素","subitem_subject_scheme":"Other"},{"subitem_subject":"アイソフォーム","subitem_subject_scheme":"Other"},{"subitem_subject":"8-Hydroxy-2'-deoxyguanosine","subitem_subject_scheme":"Other"},{"subitem_subject":"活性窒素3-Nitrotyrosine","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アトピー性皮膚炎モデルNC/Ngaマウスにおける一酸化窒素および活性窒素種の関与に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アトピー性皮膚炎モデルNC/Ngaマウスにおける一酸化窒素および活性窒素種の関与に関する研究"}]},"item_type_id":"7","owner":"3","path":["1316"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17104","relation_version_is_last":true,"title":["アトピー性皮膚炎モデルNC/Ngaマウスにおける一酸化窒素および活性窒素種の関与に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:08:11.313152+00:00"}