{"created":"2023-07-27T06:31:37.947008+00:00","id":17125,"links":{},"metadata":{"_buckets":{"deposit":"ef615595-24d9-4c0b-ad61-f8057aa3eb32"},"_deposit":{"created_by":3,"id":"17125","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17125"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017125","sets":["1132:1137:1270:1319"]},"author_link":["582"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4・5・6","bibliographicPageEnd":"150","bibliographicPageStart":"140","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2004131467","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"髄芽腫24例の手術標本を対象に,Wntシグナル関連分子について,免疫組織化学的,および分子生物学的に解析した.γ-カテニンの細胞質/細胞膜陽性所見を9例(37%)に認め,陽性群は陰性群より有意に予後良好であった.また,診察時に髄腔内播種を認めなかった症例も,播種を認めた症例より有意に予後良好であった.β-カテニンの細胞質/細胞膜陽性所見を19例(79%)に,cyclin D1,およびc-mycの核染色を6例(25%),21例(83%)に認めた.cyclin D1陽性群は,髄腔内播種の有無に関わらず,全例死亡した.弁別式PCRでは,c-myc,N-mycとも1例ずつ遺伝子増幅が検出された.両症例ともlarge cell/anaplastic typeで,c-myc増幅例は術後6ヵ月で腫瘍死したが,N-myc増幅例は術後10年以上生存した.髄芽腫の予後を予測し,治療を個別化する上で,γ-カテニンの免疫組織化学的検索は有用だと考えられ,cyclin D1の免疫組織化学的評価は予後を確定する指標となる可能性が示された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科脳医科学専攻脳機能制御学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"見崎, 孝一"}],"nameIdentifiers":[{"nameIdentifier":"582","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20507082","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=20507082"},{"nameIdentifier":"20507082","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20507082"},{"nameIdentifier":"20507082","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020507082"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-015-misaki.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-015-misaki.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17125/files/C0000002237-015-misaki.pdf"},"version_id":"1988ebca-e177-4b3b-84dd-b06a5226ccba"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"myc癌原遺伝子蛋白質(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞遺伝学","subitem_subject_scheme":"Other"},{"subitem_subject":"髄芽細胞腫(病理学,遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"脳腫瘍(病理学,遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin D1(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"Desmoplakins(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"乳児(1～23ヶ月)","subitem_subject_scheme":"Other"},{"subitem_subject":"幼児(2～5)","subitem_subject_scheme":"Other"},{"subitem_subject":"小児(6～12)","subitem_subject_scheme":"Other"},{"subitem_subject":"青年期(13～18)","subitem_subject_scheme":"Other"},{"subitem_subject":"成人(19～44)","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"髄芽腫における免疫組織化学的及び細胞遺伝学的異常とその臨床的意義　c-myc,N-myc,β-,γ-カテニン,cyclin D1に着目して","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"髄芽腫における免疫組織化学的及び細胞遺伝学的異常とその臨床的意義　c-myc,N-myc,β-,γ-カテニン,cyclin D1に着目して"}]},"item_type_id":"7","owner":"3","path":["1319"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17125","relation_version_is_last":true,"title":["髄芽腫における免疫組織化学的及び細胞遺伝学的異常とその臨床的意義　c-myc,N-myc,β-,γ-カテニン,cyclin D1に着目して"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:50.120564+00:00"}