{"created":"2023-07-27T06:31:37.989885+00:00","id":17126,"links":{},"metadata":{"_buckets":{"deposit":"f2005429-4875-4aab-aa94-3e8623acbc7f"},"_deposit":{"created_by":3,"id":"17126","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17126"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017126","sets":["1132:1137:1270:1319"]},"author_link":["446"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4・5・6","bibliographicPageEnd":"159","bibliographicPageStart":"151","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2004131468","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"口腔扁平上皮癌の浸潤先進部におけるP53蛋白,p21蛋白,増殖細胞核抗原(PCNA)の発現を検討するために,治験前生検組織66症例を用いて免疫組織化学的検討を行った.P53蛋白陽性細胞率(LI),PCNA-LI,p21-LIと原発部位,T分類,N分類,Stage分類との間に有意差は認められなかった.P53-LIとPCNA-LIは浸潤様式が高度になるにつれて増加していたが,p21-LIは減少していた.さらに,浸潤様式4D型のP53-LIは,各浸潤様式のP53-LIとの間に有意差が認められた.各蛋白の相関関係においては,P53-LIが高値の症例ではPCNA-LIも高値を示し,統計学的に相関が認められた.また,P53-LIが高値の症例ではp21-LIは低値を示した.所属リンパ節転移に転移を認めた症例では,P53-LIが有意に高値を示していた.P53-LIが25%以下の症例の5年生存率は,P53-LIが25%以上の症例と比べ,有意に高かった.P53は,口腔扁平上皮癌の増殖と浸潤に重要な役割を果たしていることが示唆された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文/比較研究","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科がん医科学専攻細胞浸潤学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 広禄"}],"nameIdentifiers":[{"nameIdentifier":"446","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30444201","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=30444201"},{"nameIdentifier":"30444201","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000030444201"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-015-kato.pdf","filesize":[{"value":"2.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-015-kato.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17126/files/C0000002237-015-kato.pdf"},"version_id":"c22b663a-0a9b-4a63-a887-1a56f3337f00"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"口腔腫瘍(悪性,病理学,診断)","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍侵入性","subitem_subject_scheme":"Other"},{"subitem_subject":"生存率","subitem_subject_scheme":"Other"},{"subitem_subject":"p53 Protein(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"扁平上皮癌(病理学,診断)","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学","subitem_subject_scheme":"Other"},{"subitem_subject":"Proliferating Cell Nuclear Antigen(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclin-Dependent Kinase Inhibitor p21(薬理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"成人(19～44)","subitem_subject_scheme":"Other"},{"subitem_subject":"中年(45～64)","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者(65～79)","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者-80歳以上","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"口腔扁平上皮癌の浸潤先進部におけるp53及びその関連蛋白の発現に関する免疫組織化学的研究　特にp53陽性細胞率検索の意義について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"口腔扁平上皮癌の浸潤先進部におけるp53及びその関連蛋白の発現に関する免疫組織化学的研究　特にp53陽性細胞率検索の意義について"}]},"item_type_id":"7","owner":"3","path":["1319"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17126","relation_version_is_last":true,"title":["口腔扁平上皮癌の浸潤先進部におけるp53及びその関連蛋白の発現に関する免疫組織化学的研究　特にp53陽性細胞率検索の意義について"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:49.156094+00:00"}