{"created":"2023-07-27T06:31:38.806915+00:00","id":17145,"links":{},"metadata":{"_buckets":{"deposit":"ca996021-b10f-4ee1-8edd-e5c23c5498c6"},"_deposit":{"created_by":3,"id":"17145","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17145"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017145","sets":["1132:1137:1270:1321"]},"author_link":["913"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"63","bibliographicPageStart":"50","bibliographicVolumeNumber":"112","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003278079","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"髄膜腫82例を対象にゴナドトロピン放出ホルモン受容体(GnRH-R)及びゴナドトロピン放出ホルモン(GnRH)の発現を免疫組織化学法とRT-PCR法を用いて検討し,同時にプロゲステロン受容体(PgR),エストロゲン受容体(ER)と増殖能の指標であるKi-67の免疫組織化学的検討及び臨床病理学的事項との相関についても併せて検討した.髄膜腫におけるGnRH-Rの機能を評価するため,髄膜腫6例を細胞培養し,GnRHのアゴニスト及びアンタゴニスト投与による細胞増殖解析を行った.多くの髄膜腫はGnRH-Rを発現し,GnRHが細胞増殖の調節因子の一つとして働いており,一部に自巳分泌機構が存在することが示唆された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科脳医科学専攻脳機能制御学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣田, 雄一"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-013-hirota.pdf","filesize":[{"value":"3.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-013-hirota.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17145/files/C0000002237-013-hirota.pdf"},"version_id":"24ef9e2a-e66f-454e-81a5-0d046326e0a9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Gonadorelin","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍遺伝子発現調節","subitem_subject_scheme":"Other"},{"subitem_subject":"培養腫瘍細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Estrogen Receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"LHRH Receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"Progesterone Receptors","subitem_subject_scheme":"Other"},{"subitem_subject":"髄膜腫(病理学,実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"脳腫瘍(病理学,実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"Ki-67抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"成人(19～44)","subitem_subject_scheme":"Other"},{"subitem_subject":"中年(45～64)","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者(65～79)","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者-80歳以上","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"髄膜腫におけるゴナドトロピン放出ホルモン受容体(GnRH-R)及びゴナドトロピン放出ホルモン(GnRH)の発現と細胞増殖に対するGnRHの効果　臨床病理学的ならびに培養細胞を用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"髄膜腫におけるゴナドトロピン放出ホルモン受容体(GnRH-R)及びゴナドトロピン放出ホルモン(GnRH)の発現と細胞増殖に対するGnRHの効果　臨床病理学的ならびに培養細胞を用いた検討"}]},"item_type_id":"7","owner":"3","path":["1321"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17145","relation_version_is_last":true,"title":["髄膜腫におけるゴナドトロピン放出ホルモン受容体(GnRH-R)及びゴナドトロピン放出ホルモン(GnRH)の発現と細胞増殖に対するGnRHの効果　臨床病理学的ならびに培養細胞を用いた検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:30.480998+00:00"}