{"created":"2023-07-27T06:31:38.935974+00:00","id":17148,"links":{},"metadata":{"_buckets":{"deposit":"b45dd809-a2f5-4bc3-8f8f-307d64ab2b01"},"_deposit":{"created_by":3,"id":"17148","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17148"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017148","sets":["1132:1137:1270:1322"]},"author_link":["576"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"347","bibliographicPageStart":"337","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003249188","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"神経膠芽腫における染色体12番長腕12q22-23のヘテロ接合性の喪失(LOH)とApaf-1の不活化を検討した.対象は,神経膠芽腫33例で染色体12q22-23LOHとApaf-1発現の関与,p53遺伝子異常およびEGFR遺伝子増幅との関係を検討した.33例中14例(42%)にLOHを認め,14例中Apaf-1 mRNAの低発現は9例(69%),Apaf-1陰性反応は12例(86%)で,染色体12q22-23LOHとApaf-1 mRNAおよび蛋白の低発現は有意に相関した.p53遺伝子変異は13例(39%),EGFR遺伝子増幅は8例(24%)に認め,両者は互いに相容れない関係で,染色体12q22-23LOHと両者に相関関係はなかった.p53,EGFRいずれの遺伝子異常も有さず染色体12q22-23のアレル情報が得られた9例中6例(67%)にLOHを認め,LOHまたはp53遺伝子異常のいずれかを有するものは23例(70%)に上った.本疾患では「p53-Apaf-1」アポトーシス経路の破綻が考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科脳医科学専攻脳機能制御学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"渡邉, 卓也"}],"nameIdentifiers":[{"nameIdentifier":"576","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90399775","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=90399775"},{"nameIdentifier":"90399775","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000090399775"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-012-watanabe.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-012-watanabe.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17148/files/C0000002237-012-watanabe.pdf"},"version_id":"67076782-412f-4191-b46f-72fecfaac82a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子増幅","subitem_subject_scheme":"Other"},{"subitem_subject":"Epidermal Growth Factor Receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"神経膠芽腫(遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"p53 Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"変異","subitem_subject_scheme":"Other"},{"subitem_subject":"マイクロサテライトリピート","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト第12染色体","subitem_subject_scheme":"Other"},{"subitem_subject":"Loss of Heterozygosity","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現停止Apaf-1 Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"小児(6～12)","subitem_subject_scheme":"Other"},{"subitem_subject":"青年期(13～18)","subitem_subject_scheme":"Other"},{"subitem_subject":"成人(19～44)","subitem_subject_scheme":"Other"},{"subitem_subject":"中年(45～64)","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者(65～79)","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"神経膠芽腫における染色体12番長腕12q22-23のヘテロ接合性の喪失とApaf-1の不活化","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"神経膠芽腫における染色体12番長腕12q22-23のヘテロ接合性の喪失とApaf-1の不活化"}]},"item_type_id":"7","owner":"3","path":["1322"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17148","relation_version_is_last":true,"title":["神経膠芽腫における染色体12番長腕12q22-23のヘテロ接合性の喪失とApaf-1の不活化"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:27.795012+00:00"}