{"created":"2023-07-27T06:31:39.108648+00:00","id":17152,"links":{},"metadata":{"_buckets":{"deposit":"af25150a-1956-4263-b76d-9f86de55d4bf"},"_deposit":{"created_by":3,"id":"17152","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17152"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017152","sets":["1132:1137:1270:1322"]},"author_link":["623"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"299","bibliographicPageStart":"290","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003249184","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ニワトリDT40細胞を用いたチェックポイント関連遺伝子Rad9の放射線感受性に関して検討した.方法は,ニワトリのBリンパ球由来の細胞株のDT40細胞を用い,Rad9のノックアウト細胞(Rad9-/-細胞)を作成した.放射線感受性を調べるため,コロニー形成法を用いて各線量での生存率を求めた.Rad9-/-細胞は野生型に比し,いずれの線量でも生存率が低く高感受性を示したが,X線高感受性のATMのノックアウト細胞に比べると低かった.紫外線やヒドロキシ尿素に対してRad9-/-細胞は著明な高感受性を示した.細胞周期チェックポイントへの関与では,X線照射後の分裂係数の測定でRad9-/-細胞はATM-/-細胞と同様に細胞周期遅延の異常を認めた.Rad9は高等動物細胞においても,DNA損傷やDNA複製阻害に対する感受性および細胞周期チェックポイント機構に重要な役割を果たしていると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科循環医科学専攻経血管診療学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"熊野, 智康"}],"nameIdentifiers":[{"nameIdentifier":"623","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20377386","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=20377386"},{"nameIdentifier":"20377386","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000020377386"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-012-kumano.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-012-kumano.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17152/files/C0000002237-012-kumano.pdf"},"version_id":"38f16e4d-d991-428d-bf2a-e375d2acf020"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Hydroxyurea","subitem_subject_scheme":"Other"},{"subitem_subject":"X線","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞周期","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞分裂中期","subitem_subject_scheme":"Other"},{"subitem_subject":"紫外線","subitem_subject_scheme":"Other"},{"subitem_subject":"ニワトリ","subitem_subject_scheme":"Other"},{"subitem_subject":"培養細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子欠失DT40細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Rad9 Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞周期チェックポイントニワトリ","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ニワトリDT40細胞を用いたチェックポイント関連遺伝子Rad9の放射線感受性に関する検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ニワトリDT40細胞を用いたチェックポイント関連遺伝子Rad9の放射線感受性に関する検討"}]},"item_type_id":"7","owner":"3","path":["1322"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17152","relation_version_is_last":true,"title":["ニワトリDT40細胞を用いたチェックポイント関連遺伝子Rad9の放射線感受性に関する検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:24.537914+00:00"}