{"created":"2023-07-27T06:31:39.803212+00:00","id":17168,"links":{},"metadata":{"_buckets":{"deposit":"cbe44102-1200-464f-8c88-46c02e61d15e"},"_deposit":{"created_by":3,"id":"17168","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17168"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017168","sets":["1132:1137:1270:1324"]},"author_link":["30849"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2・3","bibliographicPageEnd":"151","bibliographicPageStart":"142","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003045262","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"急性リンパ性白血病(ALL)37名,急性骨髄性白血病(AML)10名,非ホジキンリンパ腫(HHL)5名と正常対照169名からのヒトのシチジンデアミナーゼ(HCDA)cDNAを,直接シークエンスして一塩基変異多型(SNP)を同定し,機能を検討した.SNPの機能は酵母遺伝子発現システムを用い,酵母の増殖抑制法により,原型HCDAと変異HCDA導入酵母株シトシンアラビノシド(ara-C)に対する感受性を測定した.HCDA遺伝子の翻訳領域に同定されたSNPはA79C,G208A,T435Cで,疾患との関連は認めなかった.SNP G208は,HCDAの酵素活性領域に存在し種属間で良く保存されているAlaを,Thrに置換(A70T)した.変異導入酵母株HCDA-70Tの脱アミノ活性は,酵母への変異HCDA-208A遺伝子導入により有意に低下し,ara-Cへの感受性が高まった","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科循環医科学専攻血管発生発達病態学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岳, 麗杰"}],"nameIdentifiers":[{"nameIdentifier":"30849","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-010-gaku.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-010-gaku.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17168/files/C0000002237-010-gaku.pdf"},"version_id":"388855c5-dc16-4a85-807f-f6c5fa35838b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cytarabine","subitem_subject_scheme":"Other"},{"subitem_subject":"Cytidine Deaminase","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA配列分析","subitem_subject_scheme":"Other"},{"subitem_subject":"SNPs","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒトCytidine Deaminase遺伝子における一塩基変異多型とCytosine Arabinosideに対する薬剤感受性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒトCytidine Deaminase遺伝子における一塩基変異多型とCytosine Arabinosideに対する薬剤感受性の検討"}]},"item_type_id":"7","owner":"3","path":["1324"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17168","relation_version_is_last":true,"title":["ヒトCytidine Deaminase遺伝子における一塩基変異多型とCytosine Arabinosideに対する薬剤感受性の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:10.532690+00:00"}