{"created":"2023-07-27T06:31:39.845977+00:00","id":17169,"links":{},"metadata":{"_buckets":{"deposit":"304e6f8b-0638-491f-9632-3dad1dd83419"},"_deposit":{"created_by":3,"id":"17169","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17169"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017169","sets":["1132:1137:1270:1324"]},"author_link":["30850"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2・3","bibliographicPageEnd":"161","bibliographicPageStart":"152","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003045263","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"上咽頭癌(NPC)原発巣生検標本37例を使用し,NPCにおけるEpstein-Barrウイルス(EBV)遺伝子の発現と血管新生促進因子インターロイキン(IL-8)発現との関連性を解明し,EBV遺伝子の,NPCの血管新生誘導機構への影響について検討した.免疫組織化学法より,EBVがコードする潜状膜蛋白質(LMP1),IL-8の発現と腫瘍微小血管数は有意に相関し,LMP1の発現とIL-8の発現に有意な相関を認めた.逆転写PCR法より,IL-8mRNAの発現は,EBV陰性のNPC-KT細胞クローンよりEBV陽性クローンの方が高かった.ルシフェラーゼアッセイを用いた検討より,EBV陽性クローンのうちLMP1がIL-8プロモーターを活性化し,LMP1によるIL-8誘導にはIL-8プロモーター上流に存在するNF-κB結合領域が必須であり,AP-1結合領域も一部関与していた.以上より,LMP1によるシグナル転達ではNF-κB,AP-1の活性化がIL-8遺伝子からの転写を誘導し,NPCにおける血管新生を促進する","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科脳医科学専攻感覚運動病態学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"任, 慶春"}],"nameIdentifiers":[{"nameIdentifier":"30850","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-010-nin.pdf","filesize":[{"value":"2.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-010-nin.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17169/files/C0000002237-010-nin.pdf"},"version_id":"bc2ebff6-cf6e-4de4-9069-b41be0f06d38"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヒトヘルペスウイルス4型","subitem_subject_scheme":"Other"},{"subitem_subject":"Interleukin 8","subitem_subject_scheme":"Other"},{"subitem_subject":"病的血管新生","subitem_subject_scheme":"Other"},{"subitem_subject":"鼻咽頭腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"膜蛋白質","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫組織化学Epstein-Barrウイルス関連膜抗原","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"EBウイルス膜蛋白質LMP1によるIL-8誘導と上咽頭癌血管新生に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"EBウイルス膜蛋白質LMP1によるIL-8誘導と上咽頭癌血管新生に関する研究"}]},"item_type_id":"7","owner":"3","path":["1324"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17169","relation_version_is_last":true,"title":["EBウイルス膜蛋白質LMP1によるIL-8誘導と上咽頭癌血管新生に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:07:09.737924+00:00"}