{"created":"2023-07-27T06:31:39.889117+00:00","id":17170,"links":{},"metadata":{"_buckets":{"deposit":"66b34c91-4550-4ff1-9918-b08f56963375"},"_deposit":{"created_by":3,"id":"17170","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17170"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017170","sets":["1132:1137:1270:1324"]},"author_link":["30851"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2・3","bibliographicPageEnd":"172","bibliographicPageStart":"162","bibliographicVolumeNumber":"111","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2003045264","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"カロリ病モデル多発嚢胞腎(PCK)ラットから肝内胆管上皮細胞を単離して培養し,細胞増殖活性と遺伝子発現を調査し生物学的特性について検討した.対照はSpargue-Dawley系ラットである.PCKラットの細胞は,倍加時間が対照ラットより短く増殖活性が高かった.DNAマイクロアレイにより,細胞の増殖シグナルおよび増殖抑制シグナル伝達に影響する遺伝子の発現は,対照ラットよりPCKラットの方が亢進していた.以上より,PCKラットでは,肝内胆管拡張の発生に,遺伝子レベルの細胞増殖制御の不調和による胆管上皮細胞の異常増殖が関与していると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学大学院医学系研究科がん医科学専攻形態機能病理学","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木澤, 和夫"}],"nameIdentifiers":[{"nameIdentifier":"30851","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-010-kizawa.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-010-kizawa.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17170/files/C0000002237-010-kizawa.pdf"},"version_id":"7c1deda1-b8df-4b7a-8fb4-b3022755189d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Caroli病(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"肝内胆管","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"腎嚢胞-多発性","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞培養技術","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"カロリ病モデルPCKラットからの肝内胆管上皮細胞の単離,培養ならびにその生物学的特性の検討　細胞増殖活性及び細胞増殖関連遺伝子発現を中心に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"カロリ病モデルPCKラットからの肝内胆管上皮細胞の単離,培養ならびにその生物学的特性の検討　細胞増殖活性及び細胞増殖関連遺伝子発現を中心に"}]},"item_type_id":"7","owner":"3","path":["1324"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17170","relation_version_is_last":true,"title":["カロリ病モデルPCKラットからの肝内胆管上皮細胞の単離,培養ならびにその生物学的特性の検討　細胞増殖活性及び細胞増殖関連遺伝子発現を中心に"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-05-28T07:01:16.491531+00:00"}