{"created":"2023-07-27T06:31:40.621845+00:00","id":17187,"links":{},"metadata":{"_buckets":{"deposit":"8601e91a-efba-4269-bc0d-329d56858713"},"_deposit":{"created_by":3,"id":"17187","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17187"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017187","sets":["1132:1137:1270:1326"]},"author_link":["30865"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5・6","bibliographicPageEnd":"347","bibliographicPageStart":"339","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002259543","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"局所投与によるフルコナゾール(FLCZ)の眼内移行と前眼部への影響について検討した.実験には白色ウサギを使用し,0.2%FLCZを5分毎13回(1時間)点眼した群,30分毎25回(12時間)群,0.3mlを結膜下注射した群に分け,対照眼には生理食塩水を点眼した.1時間点眼群のFLCZ濃度は最終点眼15～30分後に結膜,角膜,前房水,虹彩毛様体,網膜および強膜において最高値となった.12時間点眼群では最終点眼1時間後に結膜,角膜,前房水および水晶体前皮質部にFLCZが検出され,結膜下注射群では前眼部組織,硝子体,網膜,脈絡膜および強膜にFLCZが検出された.角膜上皮および内皮細胞密度,角膜厚,眼圧,涙液内LDH活性および蛋白濃度は点眼前後で明らかな変化はなかった.角膜上皮創治癒速度は,点眼群と対照群間に差はみられなかった.以上より,FLCZは局所投与で前眼部組織内にCandida albicansの99%発育阻止濃度を凌駕して移行し,副作用もなく,眼真菌感染症の治療に有効かつ安全と考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究脳医科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内山, 佳代"}],"nameIdentifiers":[{"nameIdentifier":"30865","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-008-uchiyama.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-008-uchiyama.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17187/files/C0000002237-008-uchiyama.pdf"},"version_id":"35f8ed77-2447-41a7-a006-9e3ad3b01bec"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Fluconazole(薬理学,治療的利用)","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜疾患(実験的,薬物療法)","subitem_subject_scheme":"Other"},{"subitem_subject":"結膜","subitem_subject_scheme":"Other"},{"subitem_subject":"前眼房","subitem_subject_scheme":"Other"},{"subitem_subject":"創傷治癒","subitem_subject_scheme":"Other"},{"subitem_subject":"注射","subitem_subject_scheme":"Other"},{"subitem_subject":"点眼剤","subitem_subject_scheme":"Other"},{"subitem_subject":"局所投与","subitem_subject_scheme":"Other"},{"subitem_subject":"ウサギ目ウサギ","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"局所投与によるフルコナゾールの眼内移行と前眼部への影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"局所投与によるフルコナゾールの眼内移行と前眼部への影響"}]},"item_type_id":"7","owner":"3","path":["1326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17187","relation_version_is_last":true,"title":["局所投与によるフルコナゾールの眼内移行と前眼部への影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:52.952278+00:00"}