{"created":"2023-07-27T06:31:40.665361+00:00","id":17188,"links":{},"metadata":{"_buckets":{"deposit":"f547084e-3c8b-45f6-971f-167f6b3bac9b"},"_deposit":{"created_by":3,"id":"17188","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17188"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017188","sets":["1132:1137:1270:1326"]},"author_link":["30866"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5・6","bibliographicPageEnd":"359","bibliographicPageStart":"348","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002164781","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Brugada症候群の臨床的特徴と心筋Naチャネル遺伝子に関して分子遺伝学的に検討した.対象は,北陸地方のBrugada症候群患者40例(男性37例,女性3例・平均年齢50歳)であった.心室細動あるいは失神発作を17%に認め,発作性心房細動は25%と高率で,不整脈事象では14例中13例が夜間から早朝に発生し,発生直後のSTは13例中10例で前後の心電図に比し上昇していた.SCN5A遺伝子変異の検討では,1症例でエクソン7の282番目のアミノ酸ArgをコードするコドンCGCがHisをコードするCACへと変化する変異Arg282His,6症例でエクソン12の568番目のアミノ酸HisをコードするCACがArgをコードするCGCへと変化する変異His568Arg,2症例でエクソン18の1090番目のアミノ酸ProをコードするCCGがLeuをコードするCTGへと変化する変異Pro1090Leu,5症例でエクソン20の1193番目のアミノ酸ArgをコードするCGGがGlnをコードするCAGへと変化する変異Arg1193Glnを検出した.これらはすべてドメインを結ぶ細胞内ループ上の変異で遺伝子多型であった","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究循環医","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤, 英樹"}],"nameIdentifiers":[{"nameIdentifier":"30866","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-008-ito.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-008-ito.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17188/files/C0000002237-008-ito.pdf"},"version_id":"30103fb7-768b-4b1d-a881-5a62a73041a5"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Sodium Channels","subitem_subject_scheme":"Other"},{"subitem_subject":"脚ブロック","subitem_subject_scheme":"Other"},{"subitem_subject":"症候群","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋","subitem_subject_scheme":"Other"},{"subitem_subject":"心室細動","subitem_subject_scheme":"Other"},{"subitem_subject":"変異","subitem_subject_scheme":"Other"},{"subitem_subject":"不整脈","subitem_subject_scheme":"Other"},{"subitem_subject":"分子生物学","subitem_subject_scheme":"Other"},{"subitem_subject":"突然死-心臓","subitem_subject_scheme":"Other"},{"subitem_subject":"Brugada症候群(遺伝学)SCN5A Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"男","subitem_subject_scheme":"Other"},{"subitem_subject":"女","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Brugada症候群の臨床的特徴と心筋Naチャネル遺伝子に関する分子遺伝学的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Brugada症候群の臨床的特徴と心筋Naチャネル遺伝子に関する分子遺伝学的研究"}]},"item_type_id":"7","owner":"3","path":["1326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17188","relation_version_is_last":true,"title":["Brugada症候群の臨床的特徴と心筋Naチャネル遺伝子に関する分子遺伝学的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:52.136885+00:00"}