{"created":"2023-07-27T06:31:40.750689+00:00","id":17190,"links":{},"metadata":{"_buckets":{"deposit":"f7f58fc4-e946-4cb5-901d-daa6de6eaf4c"},"_deposit":{"created_by":3,"id":"17190","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17190"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017190","sets":["1132:1137:1270:1326"]},"author_link":["30867"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5・6","bibliographicPageEnd":"380","bibliographicPageStart":"370","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002184989","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ヒト水晶体における新規蛍光物質の同定について検討した.材料は老人性白内障核で,褐色白内障核(褐色核)と非褐色核に分けて比較した.蛍光物質の3HK-Glc,キヌレニン,DHKN-Glcの含有量は両者間で有意差はなかったが,未同定の蛍光物質(Fl-Glc)が褐色核で著明に増加していた.非褐色核由来の低分子分画を長期静置すると未知の蛍光物質(Fl-X)が著明に増加した.HPLCによるFl-GlcとFl-Xの比較では,異なる二つの条件下で両者の保持時間は一致し,両者の蛍光ピークはβ-グルコシダーゼ処理で消失し,両者は同一物質であると結論された.質量分析ではFl-XのMWが367で,そのアグリコンのMWは205と推定され,Fl-XのアグリコンのHPLC上の保持時間はキサンツレン酸(MW205)のそれと一致し,Fl-X(=Fl-Glc)はキサンツレン酸のβ-グルコシドであると推論した.また,3HK-GlcにPLPを添加し長期静置すると,Fl-Glcと同一保持時間の蛍光物質が著増することより,非酵素的に生成されるものと考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究脳医科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安藤, 佳奈子"}],"nameIdentifiers":[{"nameIdentifier":"30867","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-008-ando.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-008-ando.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17190/files/C0000002237-008-ando.pdf"},"version_id":"c7e1f351-73de-4ef9-9c19-0dfecdde70f7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Glucosides","subitem_subject_scheme":"Other"},{"subitem_subject":"質量分析","subitem_subject_scheme":"Other"},{"subitem_subject":"水晶体","subitem_subject_scheme":"Other"},{"subitem_subject":"白内障","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒトXanthurenic Acid","subitem_subject_scheme":"Other"},{"subitem_subject":"蛍光物質","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"老年者(65～)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト水晶体における新規蛍光物質の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト水晶体における新規蛍光物質の同定"}]},"item_type_id":"7","owner":"3","path":["1326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17190","relation_version_is_last":true,"title":["ヒト水晶体における新規蛍光物質の同定"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:50.506067+00:00"}