{"created":"2023-07-27T06:31:40.836871+00:00","id":17192,"links":{},"metadata":{"_buckets":{"deposit":"0e70a57c-876f-4363-9935-60fa51532c02"},"_deposit":{"created_by":3,"id":"17192","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17192"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017192","sets":["1132:1137:1270:1326"]},"author_link":["30869"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5・6","bibliographicPageEnd":"403","bibliographicPageStart":"390","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002166186","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"角膜上皮細胞におけるKチャンネルのアラキドン酸による調節について検討した.対象は,ウシ角膜とヒト角膜で,角膜上皮細胞を単離した.ウシ角膜上皮細胞には,極性に乏しい球状細胞と極性を有する円柱状細胞の2種類と,2種類のK電流が認められた.一つは,不活性化K電流で,膜電位開口型Kチャンネルのそれに類似し,円柱状細胞に多く発現した.一つは,不活性化しないK電流で,ウサギ角膜上皮の大コンダクタンスK電流に相同の持続型K電流で,このK電流はアラキドン酸により著明に増大した.アラキドン酸代謝の基質にならない脂肪酸も同様に作用し,アラキドン酸は直接Kチャンネルに作用すると考えられた.アラキドン酸や脂肪酸は,不活性化K電流には抑制的に作用した.ヒト角膜上皮細胞では不活性化電流は認めず,アラキドン酸,脂肪酸により増大した電流は+10mVより陽性で強い整流作用を示し,ジルチアゼムには阻害されなかった.100μMアラキドン酸は,ジルチアゼム感受性のK電流を増大させ,ヒト角膜上皮細胞でも持続型K電流が発現すると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究脳医科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"櫻田, 規全"}],"nameIdentifiers":[{"nameIdentifier":"30869","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-008-sakurada.pdf","filesize":[{"value":"1.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-008-sakurada.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17192/files/C0000002237-008-sakurada.pdf"},"version_id":"d669204e-61ba-4e21-846a-fe6e0b798cf8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Arachidonic Acid","subitem_subject_scheme":"Other"},{"subitem_subject":"Potassium Channels","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪酸","subitem_subject_scheme":"Other"},{"subitem_subject":"パッチクランプ法","subitem_subject_scheme":"Other"},{"subitem_subject":"角膜上皮","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"ウシ","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"角膜上皮におけるKチャンネルのアラキドン酸による調節","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"角膜上皮におけるKチャンネルのアラキドン酸による調節"}]},"item_type_id":"7","owner":"3","path":["1326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17192","relation_version_is_last":true,"title":["角膜上皮におけるKチャンネルのアラキドン酸による調節"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:48.889524+00:00"}