{"created":"2023-07-27T06:31:40.923073+00:00","id":17194,"links":{},"metadata":{"_buckets":{"deposit":"2fbb6a2f-c76d-4b8f-a3eb-d5bbb65a1dd8"},"_deposit":{"created_by":3,"id":"17194","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17194"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017194","sets":["1132:1137:1270:1326"]},"author_link":["30871"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"5・6","bibliographicPageEnd":"442","bibliographicPageStart":"418","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002182321","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"自然発症インスリン非依存型糖尿病ラット(OLETF)の網膜電図(ERG)に関して検討した.実験には,OLETFラットと糖尿病を発病しないLETOラットを用い,自由摂食のOLETF,食事制限のOLETF,LETOの3群に分け,ERGの経時的変化を比較した.自由摂食群はLETOに比し,糖尿病状態にある35週齢以後でもO2,O3,O4振幅は有意に大きく,網膜ドーパミン,DOPAC含量が有意に高く,高血糖以外のOLETF特有の因子の関与が示唆された.自由摂食群は食事制限群に比し,耐糖能障害をきたし始める15,20週齢でO2頂点潜時は有意に短縮し,35週齢よりO2,O3の頂点潜時延長と振幅低下を認めた.55週齢OLETFでは血清総コレステロール,HDLコレステロール値,血清トリグリセリド値はO1,O2,O3,O4の頂点潜時と正の相関を示した.55週齢のDOPAC,HVAは,自由摂食群が食事制限群に比し有意に低く,O1,O2,O3の頂点潜時と負の相関を示した.以上より,脂質代謝異常ないし網膜内ドーパミン代謝異常が網膜機能失調に関与していることがERGにより確認された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究脳医科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山田, 陽久"}],"nameIdentifiers":[{"nameIdentifier":"30871","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-008-yamada.pdf","filesize":[{"value":"3.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-008-yamada.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17194/files/C0000002237-008-yamada.pdf"},"version_id":"f89d41f9-4733-4153-a23e-9188d98354a3"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dopamine","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病-2型","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病網膜症","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜電図栄養制限食","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"自然発症糖尿病ラットの網膜電図に関する研究　食餌制限の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"自然発症糖尿病ラットの網膜電図に関する研究　食餌制限の効果"}]},"item_type_id":"7","owner":"3","path":["1326"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17194","relation_version_is_last":true,"title":["自然発症糖尿病ラットの網膜電図に関する研究　食餌制限の効果"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:47.251730+00:00"}