{"created":"2023-07-27T06:31:41.310580+00:00","id":17203,"links":{},"metadata":{"_buckets":{"deposit":"31d841a1-71be-402b-809f-5ddc79dc6221"},"_deposit":{"created_by":3,"id":"17203","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17203"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017203","sets":["1132:1137:1270:1327"]},"author_link":["30879"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-08-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4・5","bibliographicPageEnd":"294","bibliographicPageStart":"283","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2002106966","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"末梢神経損傷後における酸化型ガレクチン-1の軸索再生促進効果の機序を明らかにする為に,正常末梢神経におけるgal-1の発現を免疫組織化学,イムノブロットで検討し,ラットを用いて軸索損傷モデルを作成し,再生軸索,遊走シュワン細胞の動態を検索した.ガレクチン-1はラット坐骨神経内,軸索,シュワン細胞,後根神経節細胞,脊髄前角運動神経細胞に発現していた.rh-gal-lox投与で感覚神経および運動神経の軸索再生が共に促進され,抗ガレクチン-1中和抗体で両者よりの軸索再生が共に抑制された.近位シュワン細胞,遠位シュワン細胞の遊走は共にrh-gal-lox投与で促進され,抗ガレクチン-1中和抗体投与で両者の遊走は抑制された.酸化型ガレクチン-1は,再生軸索との接触に関係なくシュワン細胞の遊走を促進している.末梢神経損傷後,酸化型ガレクチン-1は,シュワン細胞の遊走促進効果を介して感覚神経軸索,運動神経軸索の再生を促進していると考えられた","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医系研究脳医科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"深谷, 賢司"}],"nameIdentifiers":[{"nameIdentifier":"30879","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-007-fukaya.pdf","filesize":[{"value":"3.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-007-fukaya.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17203/files/C0000002237-007-fukaya.pdf"},"version_id":"871b87d5-372b-4190-adcb-0a27e70aa931"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Schwann細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"軸索","subitem_subject_scheme":"Other"},{"subitem_subject":"神経再生","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄神経","subitem_subject_scheme":"Other"},{"subitem_subject":"末梢神経系疾患(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"神経移植","subitem_subject_scheme":"Other"},{"subitem_subject":"Galectin-1(薬理学,治療的利用)","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"脊髄神経損傷後の軸索変性-再生過程に与える酸化型ガレクチン-1の効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脊髄神経損傷後の軸索変性-再生過程に与える酸化型ガレクチン-1の効果"}]},"item_type_id":"7","owner":"3","path":["1327"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17203","relation_version_is_last":true,"title":["脊髄神経損傷後の軸索変性-再生過程に与える酸化型ガレクチン-1の効果"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:39.750194+00:00"}