{"created":"2023-07-27T06:31:41.826536+00:00","id":17215,"links":{},"metadata":{"_buckets":{"deposit":"8676f814-d7c2-4426-b1ec-4841112aea24"},"_deposit":{"created_by":3,"id":"17215","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17215"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017215","sets":["1132:1137:1270:1329"]},"author_link":["30885"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"30","bibliographicPageStart":"16","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2001239474","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"BALB/cマウスおよび機能的Fas欠損マウスC3H/lprマウスの培養肝内胆管上皮およびPBC肝組織を用い,免疫組織化学的および分子生物学的に胆管上皮アポトーシスの発生機序を検討した.BALB/cマウス肝内胆管上皮培養系にNFκB阻害剤であるラクタシスチンを添加した結果,6～12時間後にアポトーシスの亢進がみられた.同時期にFas/Fas-L発現が亢進し,又,2～6時間でFas-LmRNA発現が亢進した.Fas/Fas-L系がNFκB阻害による胆管上皮アポトーシス機序の一つであることが示唆された.これらの結果マウス培養肝内胆管上皮およびヒト肝組織を用いた検討で,NFκB減少状態,IL1β発現減少状態が,肝内胆管上皮のアポトーシスに関連し,最終的なエフェクタープロセスとしてFas/Fas-L系の関与が示唆された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医第1内科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"齋藤, 孝仁"}],"nameIdentifiers":[{"nameIdentifier":"30885","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-005-saito.pdf","filesize":[{"value":"4.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-005-saito.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17215/files/C0000002237-005-saito.pdf"},"version_id":"e9e0cec9-bbb0-4b06-a2e8-d2c58dc6ca1d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝硬変-胆汁性(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"肝内胆管","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮","subitem_subject_scheme":"Other"},{"subitem_subject":"胆管","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"C3Hマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"FasL ProteinLactacystin","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ラクタシスチンによるマウス培養肝内胆管上皮のアポトーシス誘導　原発性胆汁性肝硬変での胆管アポトーシスとの比較を中心に","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ラクタシスチンによるマウス培養肝内胆管上皮のアポトーシス誘導　原発性胆汁性肝硬変での胆管アポトーシスとの比較を中心に"}]},"item_type_id":"7","owner":"3","path":["1329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17215","relation_version_is_last":true,"title":["ラクタシスチンによるマウス培養肝内胆管上皮のアポトーシス誘導　原発性胆汁性肝硬変での胆管アポトーシスとの比較を中心に"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:28.561994+00:00"}