{"created":"2023-07-27T06:31:41.955020+00:00","id":17218,"links":{},"metadata":{"_buckets":{"deposit":"21dd2be4-cb8b-46bf-84ea-208f4bdf7b00"},"_deposit":{"created_by":3,"id":"17218","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17218"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017218","sets":["1132:1137:1270:1329"]},"author_link":["595"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"52","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2001249059","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"60例のヒト膵癌組織材料を用い,免疫組織学的検討よりp16蛋白の発現を検討し,DNAを用いたホモ接合性欠失,変異,メチル化等のp16遺伝子異常を検索した.その結果,ヒト膵癌60例のp16の異常は,蛋白発現レベルで38例,遺伝子レベルで11例にみられた.変異レベルでp16の変異がみられた9症例の内訳は,エクソン1が2例,エクソン2が7例であった.又,メチル化は2例でみられた.遺伝子レベルの異常の有無では占拠部位,組織型,臨床病期に有意差はみとめなかったが,p16遺伝子異常群は正常群に比し,腫瘍径が大きく,術後6ヵ月以内に死亡した者が多かった.以上よりp16を有する膵癌は悪性度が高く,予後不良予測マーカーとなり得ることを示す","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学がん研究所","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"大坪, 公士郎"}],"nameIdentifiers":[{"nameIdentifier":"595","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60361987","nameIdentifierScheme":"e-Rad","nameIdentifierURI":"https://kaken.nii.ac.jp/ja/search/?qm=60361987"},{"nameIdentifier":"60361987","nameIdentifierScheme":"金沢大学研究者情報","nameIdentifierURI":"http://ridb.kanazawa-u.ac.jp/public/detail.php?kaken=60361987"},{"nameIdentifier":"60361987","nameIdentifierScheme":"研究者番号","nameIdentifierURI":"https://nrid.nii.ac.jp/nrid/1000060361987"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-005-otsubo.pdf","filesize":[{"value":"2.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-005-otsubo.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17218/files/C0000002237-005-otsubo.pdf"},"version_id":"ca33ceb5-55a6-4b95-ba13-4343a9fd37af"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌抑制遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"膵臓腫瘍(悪性,遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"変異","subitem_subject_scheme":"Other"},{"subitem_subject":"臨床病理学","subitem_subject_scheme":"Other"},{"subitem_subject":"p16遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"膵癌におけるp16癌抑制遺伝子の異常　臨床病理学的事項との対比","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"膵癌におけるp16癌抑制遺伝子の異常　臨床病理学的事項との対比"}]},"item_type_id":"7","owner":"3","path":["1329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17218","relation_version_is_last":true,"title":["膵癌におけるp16癌抑制遺伝子の異常　臨床病理学的事項との対比"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:26.190582+00:00"}