{"created":"2023-07-27T06:31:41.998361+00:00","id":17219,"links":{},"metadata":{"_buckets":{"deposit":"94db80ff-1e25-4888-8e0a-a2ae6972bae6"},"_deposit":{"created_by":3,"id":"17219","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17219"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017219","sets":["1132:1137:1270:1329"]},"author_link":["30888"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"76","bibliographicPageStart":"65","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2001245267","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"髓膜腫の腫瘍化における酸化ストレスの役割を解明する為に腫瘍抑制蛋白質マーリンと分解酵素カルパインとの相関についてU251MG細胞と髓膜腫細胞を用いて検索し次の結果を得た.U251MG細胞において酸化ストレスにおけるμ-カルパインの活性化とマーリンの分解と分解産物を認め,髓膜腫細胞でも同様の結果を得た.又,U251MG細胞と髓膜腫細胞において酸化ストレス後にカルパスタチンの分解がみられ,U251MG細胞および髓膜腫細胞においてZ-LLaI処理により,マーリンおよびカルパスタチンの分解がみられた.これらの結果より中高年に多発する特発性髓膜腫の発生メカニズムとして,老化に伴って生ずるフリーラジカルがμ-カルパインを活性化し,マーリンを過剰分解していることが推察された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医脳神経外科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"金子, 拓郎"}],"nameIdentifiers":[{"nameIdentifier":"30888","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-005-kaneko.pdf","filesize":[{"value":"3.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-005-kaneko.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17219/files/C0000002237-005-kaneko.pdf"},"version_id":"e3958b39-f591-46bc-a33c-3e2e2f6595a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Calpain","subitem_subject_scheme":"Other"},{"subitem_subject":"髄膜腫","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"Neurofibromin 2分解","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"酸化ストレスによるμ-カルパインの活性化とNF2蛋白質(マーリン)の分解","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化ストレスによるμ-カルパインの活性化とNF2蛋白質(マーリン)の分解"}]},"item_type_id":"7","owner":"3","path":["1329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17219","relation_version_is_last":true,"title":["酸化ストレスによるμ-カルパインの活性化とNF2蛋白質(マーリン)の分解"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:25.372323+00:00"}