{"created":"2023-07-27T06:31:42.084316+00:00","id":17221,"links":{},"metadata":{"_buckets":{"deposit":"f76d027c-0566-41d2-95d8-772990c82809"},"_deposit":{"created_by":3,"id":"17221","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17221"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017221","sets":["1132:1137:1270:1329"]},"author_link":["30889"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"95","bibliographicPageStart":"87","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2001254667","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"髓膜腫の腫瘍化における酸化ストレスの役割を解明する為に,腫瘍抑制蛋白質マーリンとカルパインの相関についてU251MG細胞と髓膜腫細胞を用いて検索した.その結果,両細胞において酸化ストレスによるμ-カルパインの活性化とマーリンの分解を認めた.又,両者において酸化ストレス後にカルパインの内在性阻害蛋白質であるカルパスタチンの分解がみられ,Z-LLal処理により,マーリン及びカルパスタチンの分解抑制がみられた.又,蛍光免疫細胞化学染色により,正常マーリンと酸化ストレス後のμ-カルパインは共に形式膜で強く発現,ストレス後,マーリンは形質質から細胞質や核膜へ移動していた.これらのことから腫瘍発生の一因としてマーリンの過剰分解を推察した","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医第3内科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"明, さおり"}],"nameIdentifiers":[{"nameIdentifier":"30889","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-005-saori.pdf","filesize":[{"value":"1.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-005-saori.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17221/files/C0000002237-005-saori.pdf"},"version_id":"0513b508-094a-4973-a268-35eec6159529"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Dinoprostone","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostaglandin-Endoperoxide Synthase(治療的利用)","subitem_subject_scheme":"Other"},{"subitem_subject":"耐性因子","subitem_subject_scheme":"Other"},{"subitem_subject":"Thromboxane A2","subitem_subject_scheme":"Other"},{"subitem_subject":"抗腫瘍剤","subitem_subject_scheme":"Other"},{"subitem_subject":"肺腫瘍(悪性,薬物療法)","subitem_subject_scheme":"Other"},{"subitem_subject":"培養細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"Cyclooxygenase Inhibitors","subitem_subject_scheme":"Other"},{"subitem_subject":"　ヒト","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト肺癌細胞株の抗癌薬耐性因子としてのシクロオキシゲナーゼ-2","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト肺癌細胞株の抗癌薬耐性因子としてのシクロオキシゲナーゼ-2"}]},"item_type_id":"7","owner":"3","path":["1329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17221","relation_version_is_last":true,"title":["ヒト肺癌細胞株の抗癌薬耐性因子としてのシクロオキシゲナーゼ-2"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:23.761699+00:00"}