{"created":"2023-07-27T06:31:42.213609+00:00","id":17224,"links":{},"metadata":{"_buckets":{"deposit":"1151bb67-52e8-44cf-a96e-94005ce9dbdd"},"_deposit":{"created_by":3,"id":"17224","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17224"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017224","sets":["1132:1137:1270:1329"]},"author_link":["30892"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001-02-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"125","bibliographicPageStart":"117","bibliographicVolumeNumber":"110","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"2001249426","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"星細胞系腫瘍57例におけるDcR3遺伝子増幅,DcR3のmRNAの発現,Fas蛋白,FasL蛋白の発現を半定量的PCR法,半定量的RT-PCR法,免疫組織化学法にて検討した.その結果8例でDcR3遺伝子の増幅を認めた.DcR3mRNA発現量は神経膠芽腫で発現が高い傾向にあった.又,DcR3遺伝子増幅を含むコピー数の異常とmRNA発現量は有意に相関した.Fas蛋白は神経膠芽腫での発現が高く,FasL蛋白は星細胞腫瘍の多くの症例で認めた.以上より星細胞系腫瘍においては,DcR3の高発現がFas/FasL依存性の腫瘍細胞死を競合的に阻害することにより,腫瘍の悪性化に関与していることが示唆された","subitem_description_type":"Abstract"}]},"item_7_description_22":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"原著論文","subitem_description_type":"Other"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学医脳神経外科","subitem_description_type":"Other"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"荒川, 泰明"}],"nameIdentifiers":[{"nameIdentifier":"30892","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"C0000002237-005-arakawa.pdf","filesize":[{"value":"2.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"C0000002237-005-arakawa.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17224/files/C0000002237-005-arakawa.pdf"},"version_id":"9c9e411f-c4cc-4074-9a89-13e230cea5e9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"遺伝子増幅","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子発現","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"神経膠腫","subitem_subject_scheme":"Other"},{"subitem_subject":"星状細胞腫(遺伝学)","subitem_subject_scheme":"Other"},{"subitem_subject":"Fas抗原","subitem_subject_scheme":"Other"},{"subitem_subject":"FasL Protein","subitem_subject_scheme":"Other"},{"subitem_subject":"伊東細胞Decoy Receptor 3","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"星細胞系腫瘍におけるデコイレセプター3の遺伝子増幅と遺伝子発現の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"星細胞系腫瘍におけるデコイレセプター3の遺伝子増幅と遺伝子発現の解析"}]},"item_type_id":"7","owner":"3","path":["1329"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17224","relation_version_is_last":true,"title":["星細胞系腫瘍におけるデコイレセプター3の遺伝子増幅と遺伝子発現の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:06:21.373918+00:00"}