{"created":"2023-07-27T06:31:52.566918+00:00","id":17465,"links":{},"metadata":{"_buckets":{"deposit":"001dfb63-7479-4961-9f72-06664d30f74a"},"_deposit":{"created_by":3,"id":"17465","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17465"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017465","sets":["1132:1137:1270:1352"]},"author_link":["31077"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"724","bibliographicPageStart":"717","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997156793","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"分化度の異なる5種類のヒト膵癌培養細胞を用いて検討した. 1)mRNAレベル及び蛋白レベルにおいて,u-PAは分化度とは関係なく全種類に発現が認められたのに対し,膵トリプシノーゲンは分化型であるCapan-1,BxPC-3及びAsPC-1の3種類にのみ発現がみられた. 2)ヌードマウスの脾内移植法による肝転移発生率はCapan-1では56%,BxPC-3では50%,AsPC-1では89%と,分化型の癌で高率であったのに対し,Panc-1ならびにMIAPaCa-2の分化度の低い癌では転移が全くみられなかった.即ち,膵癌細胞の肝転移発生率は分化度ならびに膵トリプシノーゲンの発現とよく相関した. 3)インベージョンアッセイにおけるCapan-1細胞の浸潤細胞数はFOY-305により0.1μM以上で濃度依存性に減少した. 4)Capan-1細胞の脾内移植法による肝転移発生率は,FOY-305非投与群の62%に対し投与群では14%と,FOY-305投与により有意に低下した","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第2外科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"二上, 文夫"}],"nameIdentifiers":[{"nameIdentifier":"31077","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-068.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-068.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17465/files/AN00044397-105-068.pdf"},"version_id":"e530b44b-7b06-41eb-b888-d63def984b4b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Serine Endopeptidases","subitem_subject_scheme":"Other"},{"subitem_subject":"培養腫瘍細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"腫瘍転移","subitem_subject_scheme":"Other"},{"subitem_subject":"膵臓腫瘍(悪性,実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"ヌードマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"Camostat","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"ヒト膵癌の浸潤・転移におけるセリンプロテアーゼの役割に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト膵癌の浸潤・転移におけるセリンプロテアーゼの役割に関する実験的研究"}]},"item_type_id":"7","owner":"3","path":["1352"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17465","relation_version_is_last":true,"title":["ヒト膵癌の浸潤・転移におけるセリンプロテアーゼの役割に関する実験的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:57.126327+00:00"}