{"created":"2023-07-27T06:31:53.002882+00:00","id":17475,"links":{},"metadata":{"_buckets":{"deposit":"05c8e98f-9b0c-45db-9a1d-2beecbd978ad"},"_deposit":{"created_by":3,"id":"17475","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17475"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017475","sets":["1132:1137:1270:1352"]},"author_link":["31086"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"833","bibliographicPageStart":"819","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997149524","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"1)正常肝の肝内胆管上皮で軽度ではあるがIL-6の発現が見られた. 2)PBCやEBOでの障害胆管上皮で,IL-6の発現が亢進しておりIL-6 mRNAシグナルもみられ,更に,IL-6レセプターの発現もみられた. 3)ヒト胆管細胞癌の癌細胞でIL-6の発現が見られ,分化度の高いものでは,発現が強くまた広汎に発現し,分化度の低下と共にIL-6の発現の分布と強度が低下した. 4)IL-6陽性癌細胞では同陰性癌細胞より増殖活性は低く,IL-6発現は胆管細胞癌細胞増殖とは逆の関連性を示すことが示された. 5)肝内結石を合併した胆管細胞癌では,IL-6は胆管上皮ディスプラジアに発現し,胆管細胞癌の発生初期に関連する因子の1つと考えられた. 6)初代ヒト正常肝内胆管培養細胞と胆管細胞癌培養細胞でIL-6,IL-6レセプター,IL-6mRNAの発現を認めた.特に,胆管細胞癌で発現が著しく亢進していた","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第2病理","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"菅原, 浩之"}],"nameIdentifiers":[{"nameIdentifier":"31086","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-078.pdf","filesize":[{"value":"6.4 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-078.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17475/files/AN00044397-105-078.pdf"},"version_id":"ee1eccae-e017-45f0-890b-51849d6114de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Interleukin 6(性状・分布)","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓","subitem_subject_scheme":"Other"},{"subitem_subject":"肝内胆管(病理学)","subitem_subject_scheme":"Other"},{"subitem_subject":"培養腫瘍細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"胆管癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"病理学","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒト","subitem_subject_scheme":"Other"},{"subitem_subject":"in vitro","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"肝内胆管系でのインターロイキン6の発現とその病理学的意義　ヒト肝組織及び培養胆管上皮細胞を用いた検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝内胆管系でのインターロイキン6の発現とその病理学的意義　ヒト肝組織及び培養胆管上皮細胞を用いた検討"}]},"item_type_id":"7","owner":"3","path":["1352"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17475","relation_version_is_last":true,"title":["肝内胆管系でのインターロイキン6の発現とその病理学的意義　ヒト肝組織及び培養胆管上皮細胞を用いた検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:48.834088+00:00"}