{"created":"2023-07-27T06:31:53.089748+00:00","id":17477,"links":{},"metadata":{"_buckets":{"deposit":"519d36b2-a900-4640-abaf-97910ddb3456"},"_deposit":{"created_by":3,"id":"17477","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"17477"},"status":"published"},"_oai":{"id":"oai:kanazawa-u.repo.nii.ac.jp:00017477","sets":["1132:1137:1270:1352"]},"author_link":["31088"],"item_7_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1996-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"854","bibliographicPageStart":"845","bibliographicVolumeNumber":"105","bibliographic_titles":[{"bibliographic_title":"金沢大学十全医学会雑誌"}]}]},"item_7_description_16":{"attribute_name":"その他の識別子","attribute_value_mlt":[{"subitem_description":"1997151938","subitem_description_type":"Other"}]},"item_7_description_21":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"腹水肝癌AH130を移植した担癌ラットに対して,メチオニンとシスチンを欠乏させたKKM-1及び更にアルギニンを増量したKKM-2のアミノ酸インバランス輸液と抗癌剤の併用療法を行った. 1)KKM-1及びKKM-2とテガフール併用群では経口摂取群に比較して有意に腫瘍重量の減少を認めた. 2)KKM-2とテガフール併用群とKKM-2単独投与群は有意にメチオニン濃度の低下とアルギニン濃度の高値を認めた. 3)5-FU濃度は腫瘍内で著明に高く,アミノ酸インバランス輸液併用群では総合アミノ酸製剤併用群より高い傾向にあった. 4)KKM-2とテガフール併用群では有意にG0G1期細胞数の増加とG2M期細胞数の減少を認めた. 5)KKM-2とテガフール併用群では総合アミノ酸製剤とテガフール併用群,KKM-1とテガフール併用群,経口摂取群に比較して,有意にPCNA標識率の低下を認めた","subitem_description_type":"Abstract"}]},"item_7_description_5":{"attribute_name":"提供者所属","attribute_value_mlt":[{"subitem_description":"金沢大学 医 第1外科","subitem_description_type":"Other"}]},"item_7_publisher_17":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"金沢大学十全医学会"}]},"item_7_source_id_11":{"attribute_name":"NCID","attribute_value_mlt":[{"subitem_source_identifier":"AN00044397","subitem_source_identifier_type":"NCID"}]},"item_7_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-7226","subitem_source_identifier_type":"ISSN"}]},"item_7_version_type_25":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"服部, 和伸"}],"nameIdentifiers":[{"nameIdentifier":"31088","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-10-04"}],"displaytype":"detail","filename":"AN00044397-105-080.pdf","filesize":[{"value":"1.6 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00044397-105-080.pdf","url":"https://kanazawa-u.repo.nii.ac.jp/record/17477/files/AN00044397-105-080.pdf"},"version_id":"1332340f-722c-4d1b-a26e-c93a3d97ad92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amino Acids","subitem_subject_scheme":"Other"},{"subitem_subject":"肝臓腫瘍(実験的)","subitem_subject_scheme":"Other"},{"subitem_subject":"抗腫瘍剤(抗菌性・抗腫瘍性)","subitem_subject_scheme":"Other"},{"subitem_subject":"輸液","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"ラット","subitem_subject_scheme":"Other"},{"subitem_subject":"動物","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アミノ酸インバランス輸液による抗癌剤の抗腫瘍効果増強に関する基礎的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミノ酸インバランス輸液による抗癌剤の抗腫瘍効果増強に関する基礎的研究"}]},"item_type_id":"7","owner":"3","path":["1352"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-10-04"},"publish_date":"2017-10-04","publish_status":"0","recid":"17477","relation_version_is_last":true,"title":["アミノ酸インバランス輸液による抗癌剤の抗腫瘍効果増強に関する基礎的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-07-28T00:02:47.180148+00:00"}